ReviewTheScientificWorldJournal2014
Anesthetic techniques and cancer recurrence after surgery.
Review in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02786329 (The Influence of Anesthesia on Postoperative Outcome and Complications in Colorectal Cancer Patients), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Anesthesia on Postoperative Outcome and Complications in Colorectal Cancer Patients
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery.The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- Trial
- Trial
- Review
- General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description.Perioperative medicine (London, England) · 2023Article
- Comparison of volatile/inhalational and IV anesthesia in long-term survival of patients with breast cancer: a retrospective study.European journal of medical research · 2022Article
- Article
- Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway.Bioengineered · 2022Article
- The Influence of Analgesic Modalities on Postoperative Cancer Recurrence.Anesthesiology and pain medicine · 2022Review
- Application of Anesthetics in Cancer Patients: Reviewing Current Existing Link With Tumor Recurrence.Frontiers in oncology · 2022Review
- Antitumor Anesthetic Strategy in the Perioperatory Period of the Oncological Patient: A Review.Frontiers in medicine · 2022Review
- Opioid-free anesthesia versus opioid-inclusive anesthesia for breast cancer surgery: a retrospective study.Journal of anesthesia, analgesia and critical care · 2021Article
- Developing an enhanced recovery after surgery program for oncology patients who undergo hip or knee reconstruction surgery.World journal of orthopedics · 2021Review
- Effect of Isolated Serum from Breast Cancer Patients with Pectoral Nerves Block on Breast Cancer Cell Line (MDA-MB-231) Apoptosis Index.Anesthesiology and pain medicine · 2021Article
- Propofol activates AMPK to inhibit the growth of HepG2 cellsJournal of gastrointestinal oncology · 2020Article
- Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors.Cancer management and research · 2020Review
- Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity.Biological research · 2019Article
- Opioid-free mastectomy in combination with ultrasound-guided erector spinae block: A series of five cases.Indian journal of anaesthesia · 2018Article
- Tumor growth activity of duloxetine in Ehrlich carcinoma in mice.BMC research notes · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many of the most common anesthetics are used in surgical oncology, yet effects on cancer cells are still not known. Anesthesia technique could differentially affect cancer recurrence in oncologic patients undergoing surgery, due to immunosuppression, stimulation of angiogenesis, and dissemination of residual cancer cells. Data support the use of intravenous anesthetics, such as propofol anesthesia, thanks to antitumoral protective effects inhibiting cyclooxygenase 2 and prostaglandins E2 in cancer cells, and stimulation of immunity response; a restriction in the use of volatile anesthetics; restriction in the use of opioids as they suppress humoral and cellular immunity, and their chronic use favors angiogenesis and development of metastases; use of locoregional anesthesia compared with general anesthesia, as locoregional appears to reduce cancer recurrence after surgery. However, these findings must be interpreted cautiously as there is no evidence that simple changes in the practice of anesthesia can have a positive impact on postsurgical survival of cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.