Trial reportPsychopharmacology2014
Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens.
Trial report in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies.PloS one · 2021Pooled it
- Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation.Neuroscience and biobehavioral reviews · 2019Pooled it
- The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task.Human brain mapping · 2018Pooled it
- Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- A randomized placebo controlled trial demonstrates the effect of dl-methylephedrine on brain functions is weaker than that of pseudoephedrine.Scientific reports · 2024Trial
- Bupropion increases activation in nucleus accumbens during anticipation of monetary reward.Psychopharmacology · 2019Trial
- Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study.Psychopharmacology · 2019Trial
- Acute tramadol enhances brain activity associated with reward anticipation in the nucleus accumbens.Psychopharmacology · 2018Trial
- Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task.Cerebral cortex communications · 2023Article
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- A review of psychosocial factors and personality in the treatment of obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Participation of Dopamine D1 and D2 Receptors in the Rapid-Onset Behavioral Sensitization to Modafinil.Frontiers in pharmacology · 2019Article
- Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination.The international journal of neuropsychopharmacology · 2018Article
- Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil.Frontiers in pharmacology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe nucleus accumbens (NAc) works as a key brain structure of the reward system, in which reward-related neural activity is well correlated with dopamine release from mesolimbic dopaminergic neurons.
objectivesSince modafinil can modulate dopaminergic transmission through re-uptake inhibition of dopamine, we investigated whether modafinil affects the reward-related brain activity in the NAc in healthy subjects.
methodsTwenty healthy participants underwent two series of functional magnetic resonance imaging while performing monetary incentive delay task in which they were cued to anticipate and respond to a rapidly presented target to gain or avoid losing varying amounts of money, under modafinil or placebo condition. Blood oxygenation-level dependent (BOLD) activation signals during gain and loss anticipations were analyzed in the NAc as an a priori region of interest as well as the whole brain.
resultsModafinil significantly changed subjective feelings toward positive ones. The activation of BOLD signals was observed during gain anticipation under the placebo and modafinil conditions in the left and bilateral NAc, respectively. The modafinil condition showed significantly higher BOLD signal change at the highest gain (+¥500) cue compared to the placebo condition.
conclusionsThe present study showed that modafinil affects reward processing in the NAc in healthy subjects through enhancing more positive anticipation, and it may provide a basis for the use of this drug for treating anhedonia observed in psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.