ReviewPediatric nephrology (Berlin, Germany)2014
Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation.
Review in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group.Nature reviews. Nephrology · 2021Guideline
- Podocytopathies.Nature reviews. Disease primers · 2025Review
- Transient Congenital Nephrotic Syndrome in Neonates: Two Case Reports and Review of Recent Literature.Cureus · 2025Article
- Serum Factors in Primary Podocytopathies.Antibodies (Basel, Switzerland) · 2025Review
- Urinary nephrin - An emerging novel biomarker in early detection of diabetic nephropathy: A review.Bioinformation · 2025Article
- Monogenic focal segmental glomerulosclerosis: A conceptual framework for identification and management of a heterogeneous disease.American journal of medical genetics. Part C, Seminars in medical genetics · 2022Review
- Evaluation of Genetic Kidney Diseases in Living Donor Kidney Transplantation: Towards Precision Genomic Medicine in Donor Risk Assessment.Current transplantation reports · 2022Article
- Emerging Role of Clinical Genetics in CKD.Kidney medicine · 2022Review
- COQ8B glomerular nephropathy: Outcomes after kidney transplantation and analysis of characteristics in Chinese population.Frontiers in pediatrics · 2022Article
- De novo Glomerular Disease and the Significance of Electron Microscopy in Renal Transplantation.Glomerular diseases · 2021Review
- A novel mutation of congenital nephrotic syndrome in a Slovenian child eventually receiving a renal transplant.Croatian medical journal · 2021Article
- Australia and New Zealand renal gene panel testing in routine clinical practice of 542 families.NPJ genomic medicine · 2021Article
- Genetic architecture of paediatric renal diseases in China and the need for data sharing.Translational pediatrics · 2020Article
- Rare inherited kidney diseases: an evolving field in Nephrology.Jornal brasileiro de nefrologia · 2020Article
- Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association.Frontiers in medicine · 2020Review
- The Role of p.Ser1105Ser (inMedicina (Kaunas, Lithuania) · 2019Article
- Non-immunologic allograft loss in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2019Review
- Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients.Journal of the American Society of Nephrology : JASN · 2019Article
- Diagnostic and Management Challenges in Congenital Nephrotic Syndrome.Pediatric health, medicine and therapeutics · 2019Review
- Application of next-generation sequencing technology to diagnosis and treatment of focal segmental glomerulosclerosis.Clinical and experimental nephrology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal transplantation (RTx) is the only curative treatment for most cases of congenital and infantile nephrotic syndrome (NS) caused by genetic defects in glomerular podocyte proteins. The outcome of RTx in these children is usually excellent, with no recurrence of nephrotic syndrome. A subgroup of patients with the Finnish type of congenital nephrosis (CNF), shows, however, a clear risk for post-RTx proteinuria. Most of these patients have a homozygous truncating mutation (Fin-major mutation) in the nephrin gene (NPHS1), leading to total absence of the major podocyte protein, nephrin. After RTx, these patients develop anti-nephrin antibodies resulting in nephrotic range proteinuria. Plasma exchange combined with cyclophosphamide and anti-CD20 antibodies has proved to be successful therapy for these episodes. NS recurrence has also occurred in a few patients with mutations in the podocin gene (NPHS2). No anti-podocin antibodies have been detectable, and the pathophysiology of the recurrence remains open. While most of these episodes have resolved, the optimal therapy remains to be determined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.