ArticleAmerican journal of physiology. Heart and circulatory physiology2014
Effect of aging on carotid baroreflex control of blood pressure and leg vascular conductance in women.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Vascular limitations in blood pressure regulation with age in women: Insights from exercise and acute cardioselective β-blockade.Experimental physiology · 2025Article
- Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Carotid dysfunction in senescent female mice is mediated by increased αAmerican journal of physiology. Heart and circulatory physiology · 2023Article
- Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Sympathetically mediated increases in cardiac output, not restraint of peripheral vasodilation, contribute to blood pressure maintenance during hyperinsulinemia.American journal of physiology. Heart and circulatory physiology · 2020Article
- Noiseless Variable-Pressure Neck Chamber Device to Assess the Carotid Baroreflex Function.Frontiers in physiology · 2020Article
- Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Influence of physical inactivity on arterial compliance during a glucose challenge.Experimental physiology · 2018Article
- Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Article
- A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?Drugs & aging · 2016Observational
- Impaired carotid baroreflex control of arterial blood pressure in multiple sclerosis.Journal of neurophysiology · 2016Article
- Arterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients.American journal of physiology. Heart and circulatory physiology · 2016Article
- Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors.Clinical science (London, England : 1979) · 2016Review
- Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans.American journal of physiology. Heart and circulatory physiology · 2015Article
- Impaired dynamic cerebral autoregulation at rest and during isometric exercise in type 2 diabetes patients.American journal of physiology. Heart and circulatory physiology · 2015Article
- Characterizing rapid-onset vasodilation to single muscle contractions in the human leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Evidence for the emergence of leg sympathetic vasoconstrictor tone with age in healthy women.Physiological reports · 2015Article
- Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Recent work suggests that β-adrenergic vasodilation offsets α-adrenergic vasoconstriction in young women, but this effect is lost after menopause. Given these age-related vascular changes, we tested the hypothesis that older women would exhibit a greater change in vascular conductance following baroreflex perturbation compared with young women. In 10 young (21 ± 1 yr) and 10 older (62 ± 2 yr) women, mean arterial pressure (MAP; Finometer), heart rate (HR), cardiac output (CO; Modelflow), total vascular conductance (TVC), and leg vascular conductance (LVC, duplex-Doppler ultrasound) were continuously measured in response to 5-s pulses of neck suction (NS; -60 Torr) and neck pressure (NP; +40 Torr) to simulate carotid hypertension and hypotension, respectively. Following NS, decreases in MAP were similar between groups; however, MAP peak response latency was slower in older women (P < 0.05). Moreover, at the time of peak MAP, increases in LVC (young, -11.5 ± 3.9%LVC vs. older, +19.1 ± 7.0%LVC; P < 0.05) and TVC were greater in older women, whereas young women exhibited larger decreases in HR and CO (young, -10 ± 3% CO vs. older, +0.8 ± 2% CO; P < 0.05). Following NP, increases in MAP were blunted (young, +14 ± 1 mmHg vs. older, +8 ± 1 mmHg; P < 0.05) in older women, whereas MAP response latencies were similar. Interestingly, decreases in LVC and TVC were similar between groups, but HR and CO (young, +7.0 ± 2% CO vs. older, -4.0 ± 2% CO; P < 0.05) responses were attenuated in older women. These findings suggest that older women have greater reliance on vascular conductance to modulate MAP via carotid baroreflex, whereas young women rely more on cardiac responsiveness. Furthermore, older women demonstrate a blunted ability to increase MAP to hypotensive stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.