ArticleEuropean biophysics journal : EBJ2014
Membrane flickering of the human erythrocyte: constrained random walk used with Bayesian analysis.
Article in European biophysics journal : EBJ, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Surface model of the human red blood cell simulating changes in membrane curvature under strain.Scientific reports · 2021Article
- Accelerating metabolism and transmembrane cation flux by distorting red blood cells.Science advances · 2017Article
- Direct Cytoskeleton Forces Cause Membrane Softening in Red Blood Cells.Biophysical journal · 2015Article
- Membrane flickering of the human erythrocyte: physical and chemical effectors.European biophysics journal : EBJ · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of adenosine triphosphate (ATP) in erythrocyte (red blood cell; RBC) membrane flickering is of particular interest, because ATP turnover in the cell as a whole is not yet fully accounted for. We sought the origins of flickering by deriving a mathematical model of it, on the basis of the idea of thermally driven collisions of small molecules with the membrane, which responds like an over-damped spring. The model gave simulated responses that were similar to a constrained random walk and had the same frequency-spectral characteristics of membrane displacement as those recorded from RBCs by use of differential interference contrast light microscopy. Bayesian analysis was used as the basis for determination, from experimental results, of the values of the parameters in the model. The analysis was used in the accompanying article in which we investigated the response of membrane flickering to different effector molecules and physicochemical conditions. The results implied ATP was involved only indirectly in membrane flickering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.