ArticleMolecular biology and evolution2014
Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species.Genetics · 2025Article
- Regional specialization, polyploidy, and seminal fluid transcripts in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- Female reproductive fluid and male seminal fluid: a non-gametic conflict for post-mating control.Biology letters · 2023Article
- On how to identify a seminal fluid protein: A commentary on Hurtado et al.Insect molecular biology · 2022Article
- Effects of Larval Diet on the Male Reproductive Traits in the West Indian Sweet Potato WeevilsInsects · 2022Article
- The life history ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Discovering novel reproductive genes in a non-model fly usingFrontiers in genetics · 2022Article
- Recurrent Duplication and Diversification of Acrosomal Fertilization Proteins in Abalone.Frontiers in cell and developmental biology · 2022Article
- Satyrization in Drosophila fruitflies.Journal of evolutionary biology · 2021Article
- The role of female reproductive fluid in sperm competition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Post-ejaculatory modifications to sperm (PEMS).Biological reviews of the Cambridge Philosophical Society · 2020Review
- Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.Genome biology · 2019Article
- Female Genetic Contributions to Sperm Competition inGenetics · 2019Article
- Quantitative Proteomics Identification of Seminal Fluid Proteins in MaleMolecular & cellular proteomics : MCP · 2019Article
- Expression of Immune Regulatory Genes in the Porcine Internal Genital Tract Is Differentially Triggered by Spermatozoa and Seminal Plasma.International journal of molecular sciences · 2019Article
- Long-term interaction between Drosophila sperm and sex peptide is mediated by other seminal proteins that bind only transiently to sperm.Insect biochemistry and molecular biology · 2018Article
- The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo.Molecular biology and evolution · 2017Article
- The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies.Current topics in developmental biology · 2017Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gene duplication is an important mechanism for the evolution of new reproductive proteins. However, in most cases, each resulting paralog continues to function within the same sex. To investigate the possibility that seminal fluid proteins arise through duplicates of female reproductive genes that become "co-opted" by males, we screened female reproductive genes in Drosophila melanogaster for cases of duplication in which one of the resulting paralogs produces a protein in males that is transferred to females during mating. We identified a set of three tandemly duplicated genes that encode secreted serine-type endopeptidase homologs, two of which are expressed primarily in the female reproductive tract (RT), whereas the third is expressed specifically in the male RT and encodes a seminal fluid protein. Evolutionary and gene expression analyses across Drosophila species suggest that this family arose from a single-copy gene that was female-specific; after duplication, one paralog evolved male-specific expression. Functional tests of knockdowns of each gene in D. melanogaster show that one female-expressed gene is essential for full fecundity, and both female-expressed genes contribute singly or in combination to a female's propensity to remate. In contrast, knockdown of the male-expressed paralog had no significant effect on female fecundity or remating. These data are consistent with a model in which members of this gene family exert effects on females by acting on a common, female-expressed target. After duplication and male co-option of one paralog, the evolution of the interacting proteins could have resulted in differential strengths or effects of each paralog.
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