ArticleCurrent microbiology2014
Role of the siderophore transporter SirABC in the Staphylococcus aureus resistance to oxidative stress.
Article in Current microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Genetic regulation of biosynthesis and resistance to redox-active phenazines inMicrobiology spectrum · 2026Article
- Global quantitative proteome analysis of a multi-resistantFrontiers in microbiology · 2025Article
- Atacama desert actinomycetes: taxonomic analysis, drought tolerance and plant growth promoting potential.World journal of microbiology & biotechnology · 2024Article
- Non-classical roles of bacterial siderophores in pathogenesis.Frontiers in cellular and infection microbiology · 2024Review
- Siderophore for Lanthanide and Iron Uptake for Methylotrophy and Plant Growth Promotion inFrontiers in microbiology · 2022Article
- Response of the wood-decay fungus Schizophyllum commune to co-occurring microorganisms.PloS one · 2020Article
- The Role of Macrophages inFrontiers in immunology · 2020Review
- Siderophore-Mediated Iron Acquisition Enhances Resistance to Oxidative and Aromatic Compound Stress inApplied and environmental microbiology · 2019Article
- Article
- TheFrontiers in microbiology · 2017Article
- Beyond iron: non-classical biological functions of bacterial siderophores.Dalton transactions (Cambridge, England : 2003) · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Staphylococcus aureus, the intracellular siderophore staphyloferrin B, which has been shown to chelate iron-bound to serum transferrin, is transported into cells by the SirABC system. In this work, we have analysed the role of the Sir transporter under stress conditions that resemble those imposed by the mammalian innate immune system. We show that exposure of S. aureus to oxidative and nitrosative stress generated by hydrogen peroxide and S-nitrosoglutathione, respectively, induced the expression of the sirA gene. The disruption of the sir operon led to a strain with lower viability and decreased resistance to oxidative stress. S. aureus sir null mutant was also analysed during infection of murine macrophages and shown to contribute to S. aureus survival inside macrophages. Altogether, our results indicate that the Sir transport system confers protection against reactive oxygen species, therefore, contributing to the virulence of S. aureus.
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