ArticleSocial cognitive and affective neuroscience2014
'Ecstasy' as a social drug: MDMA preferentially affects responses to emotional stimuli with social content.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A Systematic Review of the MDMA Model to Address Social Impairment in Autism.Current neuropharmacology · 2021Pooled it
- The 3,4-methylenedioxymethamphetamine enhances early visual processing for salient socio-emotional stimuli.The European journal of neuroscience · 2024Trial
- Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of MDMA on attention to positive social cues and pleasantness of affective touch.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Psilocybin and MDMA reduce costly punishment in the Ultimatum Game.Scientific reports · 2018Trial
- No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.European journal of clinical pharmacology · 2018Trial
- Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.PloS one · 2018Trial
- LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Article
- MDMA as well as amphetamine and alcohol increase feelings of social closeness in healthy adults.Scientific reports · 2024Article
- The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.Current neuropharmacology · 2024Review
- Can research on entactogens contribute to a deeper understanding of human sexuality?Pharmacological reports : PR · 2023Review
- Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample.Scientific reports · 2023Article
- Potential processes of change in MDMA-Assisted therapy for social anxiety disorder: Enhanced memory reconsolidation, self-transcendence, and therapeutic relationships.Human psychopharmacology · 2022Review
- A proposed mechanism for the MDMA-mediated extinction of traumatic memories in PTSD patients treated with MDMA-assisted therapy.Frontiers in psychiatry · 2022Review
- In the face of stress: Interpreting individual differences in stress-induced facial expressions.Neurobiology of stress · 2019Review
- Serotonergic hallucinogens and recognition of facial emotion expressions: a systematic review of the literature.Therapeutic advances in psychopharmacology · 2019Review
- Regular MDMA use is associated with decreased risk of drug injection among street-involved youth who use illicit drugs.Drug and alcohol dependence · 2018Observational
- Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing.The international journal of neuropsychopharmacology · 2018Article
- MDMA does not alter responses to the Trier Social Stress Test in humans.Psychopharmacology · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is used recreationally to improve mood and sociability, and has generated clinical interest as a possible adjunct to psychotherapy. One way that MDMA may produce positive 'prosocial' effects is by changing responses to emotional stimuli, especially stimuli with social content. Here, we examined for the first time how MDMA affects subjective responses to positive, negative and neutral emotional pictures with and without social content. We hypothesized that MDMA would dose-dependently increase reactivity to positive emotional stimuli and dampen reactivity to negative stimuli, and that these effects would be most pronounced for pictures with people in them. The data were obtained from two studies using similar designs with healthy occasional MDMA users (total N = 101). During each session, participants received MDMA (0, 0.75 and 1.5 mg/kg oral), and then rated their positive and negative responses to standardized positive, negative and neutral pictures with and without social content. MDMA increased positive ratings of positive social pictures, but reduced positive ratings of non-social positive pictures. We speculate this 'socially selective' effect contributes to the prosocial effects of MDMA by increasing the comparative value of social contact and closeness with others. This effect may also contribute to its attractiveness to recreational users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.