ArticlePloS one2014
Arabidopsis transcriptome analysis reveals key roles of melatonin in plant defense systems.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it, 382 citations in OpenAlex.
- Melatonin Induced Cold Tolerance in Plants: Physiological and Molecular Responses.Frontiers in plant science · 2022Pooled it
- From night hormone to green signal: The journey of melatonin.Protoplasma · 2026Review
- Article
- Article
- Exogenous melatonin enhances the tolerance of ground-cover Chrysanthemum morifolium Ramat. to cadmium by improving photosynthetic capacity and reactive oxygen species scavenging.Plant cell reports · 2026Article
- Exogenous melatonin alleviates post-flowering natural high-temperature stress in maize (Frontiers in plant science · 2026Article
- Plant melatonin: roles and regulatory mechanisms in plant growth, development, and responses to biotic and abiotic stresses.Plant signaling & behavior · 2025Review
- Melatonin at Crossroads with Phytohormones: Interactions Under High Light Stress.International journal of molecular sciences · 2025Article
- Analysis of the AP2/ERF transcription factor family in Eriobotrya japonica and its role in exogenous melatonin-mediated regulation of salt stress.Functional & integrative genomics · 2025Article
- Melatonin Enhances Blast Disease Resistance via Inducing Rice Immunity and Inhibits the Growth of the Magnaporthe Oryzae.Rice (New York, N.Y.) · 2025Article
- Assessment of Seed Priming With Melatonin to Improve Morpho-Physiological and Biochemical Aspects of Common Bean (Plant direct · 2025Article
- Integrated Analyses Reveal the Physiological and Molecular Mechanisms of Brassinolide in Modulating Salt Tolerance in Rice.Plants (Basel, Switzerland) · 2025Article
- Role of melatonin in promoting growth attributes, thymol, rosmarinic acid and biochemical properties in Thymus vulgaris L. under water deficiency.BMC plant biology · 2025Article
- Photoreceptors Are Involved in Antioxidant Effects of Melatonin Under High Light inAntioxidants (Basel, Switzerland) · 2025Article
- Gut Microbiome-Brain Crosstalk in the Early Life of Chicken Reveals the Circadian Regulation of Key Metabolic and Immune Signaling Processes.Microorganisms · 2025Article
- Melatonin Alleviates Photosynthetic Injury in Tomato Seedlings Subjected to Salt Stress via OJIP Chlorophyll Fluorescence Kinetics.Plants (Basel, Switzerland) · 2025Article
- Integration of Phytomelatonin Signaling With Jasmonic Acid in Wound-induced Adventitious Root Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regulation of Plant Growth and Development by Melatonin.Life (Basel, Switzerland) · 2024Review
- Hydrogen peroxide mediates melatonin-induced chilling tolerance in cucumber seedlings.Plant cell reports · 2024Article
- Involvement of ROS and calcium ions in developing heat resistance and inducing antioxidant system of wheat seedlings under melatonin's effects.Protoplasma · 2024Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin is a ubiquitous molecule and exists across kingdoms including plant species. Studies on melatonin in plants have mainly focused on its physiological influence on growth and development, and on its biosynthesis. Much less attention has been drawn to its affect on genome-wide gene expression. To comprehensively investigate the role(s) of melatonin at the genomics level, we utilized mRNA-seq technology to analyze Arabidopsis plants subjected to a 16-hour 100 pM (low) and 1 mM (high) melatonin treatment. The expression profiles were analyzed to identify differentially expressed genes. 100 pM melatonin treatment significantly affected the expression of only 81 genes with 51 down-regulated and 30 up-regulated. However, 1 mM melatonin significantly altered 1308 genes with 566 up-regulated and 742 down-regulated. Not all genes altered by low melatonin were affected by high melatonin, indicating different roles of melatonin in regulation of plant growth and development under low and high concentrations. Furthermore, a large number of genes altered by melatonin were involved in plant stress defense. Transcript levels for many stress receptors, kinases, and stress-associated calcium signals were up-regulated. The majority of transcription factors identified were also involved in plant stress defense. Additionally, most identified genes in ABA, ET, SA and JA pathways were up-regulated, while genes pertaining to auxin responses and signaling, peroxidases, and those associated with cell wall synthesis and modifications were mostly down-regulated. Our results indicate critical roles of melatonin in plant defense against various environmental stresses, and provide a framework for functional analysis of genes in melatonin-mediated signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.