ArticlePloS one2014
Mouse models of anemia of cancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T.Toxicological research · 2026Article
- Comprehensive review of mouse models for studying cancer-related fatigue: Methods, findings and future directions (Review).Experimental and therapeutic medicine · 2025Review
- Iron, Copper, and Selenium: Cancer's Thing for Redox Bling.Cold Spring Harbor perspectives in medicine · 2024Review
- Unveiling the therapeutic potential: Evaluation of anti-inflammatory and antineoplastic activity ofHeliyon · 2024Article
- Article
- Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model.Haematologica · 2022Article
- Review
- Remodeling of metabolism and inflammation by exercise ameliorates tumor-associated anemia.Science advances · 2021Article
- Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.International journal of molecular sciences · 2021Review
- Review
- Immunological consequences of extramedullary erythropoiesis: immunoregulatory functions of CD71Haematologica · 2020Article
- Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review.Nutrition and cancer · 2019Review
- Increased expression of hepcidin and associated upregulation of JAK/STAT3 signaling in human gastric cancer.Oncology letters · 2018Article
- Hepcidin regulation in the anemia of inflammation.Current opinion in hematology · 2016Review
- Article
- Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.The Journal of biological chemistry · 2015Review
- Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model of multiple myeloma.Haematologica · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Anemia of cancer (AC) may contribute to cancer-related fatigue and impair quality of life. Improved understanding of the pathogenesis of AC could facilitate better treatment, but animal models to study AC are lacking. We characterized four syngeneic C57BL/6 mouse cancers that cause AC. Mice with two different rapidly-growing metastatic lung cancers developed the characteristic findings of anemia of inflammation (AI), with dramatically different degrees of anemia. Mice with rapidly-growing metastatic melanoma also developed a severe anemia by 14 days, with hematologic and inflammatory parameters similar to AI. Mice with a slow-growing peritoneal ovarian cancer developed an iron-deficiency anemia, likely secondary to chronically impaired nutrition and bleeding into the peritoneal cavity. Of the four models, hepcidin mRNA levels were increased only in the milder lung cancer model. Unlike in our model of systemic inflammation induced by heat-killed Brucella abortus, ablation of hepcidin in the ovarian cancer and the milder lung cancer mouse models did not affect the severity of anemia. Hepcidin-independent mechanisms play an important role in these murine models of AC.
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Registered trials
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