Evidence map›Paper›PMID 24681753›Full record

SynthesisScientific reports2014

Meta-analysis of infectious agents and depression.

Xiao Wang, Liang Zhang, Yang Lei, Xia Liu, Xinyu Zhou, Yiyun Liu, Mingju Wang, Liu Yang, Lujun Zhang, Songhua Fan and 1 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Cytokine Blockade Attenuates Inflammation and Improves Depressive Psychopathology After COVID-19: A Naturalistic Observational Study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiao Wang1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3].
Liang Zhang1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
Yang Lei1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
Xia Liu1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [4].
Xinyu Zhou1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yiyun Liu1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Mingju Wang1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu Yang1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China.
Lujun Zhang1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China.
Songhua Fan1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Peng Xie1] Institute of Neuroscience, Chongqing Medical University, Chongqing, China [2] Chongqing Key Laboratory of Neurobiology, Chongqing, China [3] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a debilitating psychiatric disorder and a growing global public health issue. However, the relationships between microbial infections and depression remains uncertain. A computerized literature search of Medline, ISI Web of Knowledge, PsycINFO, and the Cochrane Library was conducted up to May 2013, and 6362 studies were initially identified for screening. Case-control studies detected biomarker of microorganism were included. Based on inclusion and exclusion criteria, 28 studies were finally included to compare the detection of 16 infectious agents in unipolar depressed patients and healthy controls with a positive incident being defined as a positive biochemical marker of microbial infection. A customized form was used for data extraction. Pooled analysis revealed that the majority of the 16 infectious agents were not significantly associated with depression. However, there were statistically significant associations between depression and infection with Borna disease virus, herpes simplex virus-1, varicella zoster virus, Epstein-Barr virus, and Chlamydophila trachomatis.

Indexed as

BiomarkersCase-Control StudiesChlamydophilaChlamydophila InfectionsCommunicable DiseasesDepressionHumansVirusesBiomarkers

Identifiers

PMID24681753
PMCPMC5380112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.