ArticleInflammatory bowel diseases2014
Vitamin D levels in adults with Crohn's disease are responsive to disease activity and treatment.
Article in Inflammatory bowel diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Micronutrient Status in Adult Crohn's Disease during Clinical Remission: A Systematic Review.Nutrients · 2023Pooled it
- Pooled it
- Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza and Upper Respiratory Infection in Patients With Inflammatory Bowel Disease.Inflammatory bowel diseases · 2019Trial
- Developing a protocol to counteract spontaneous in vitro activation of intestinal fibroblasts using design of experiments.npj biomedical innovations · 2026Article
- Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistical Optimization.Research square · 2025Article
- Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?Reviews in endocrine & metabolic disorders · 2023Review
- Machine Learning Can Predict the Probability of Biologic Therapy in Patients with Inflammatory Bowel Disease.Journal of clinical medicine · 2022Article
- The Role of Vitamin D in Immune System and Inflammatory Bowel Disease.Journal of inflammation research · 2022Review
- Severe Crohn's Disease With Intra-abdominal Fistula: First Reported Case From Tanzania.Cureus · 2022Article
- Vitamin D Deficiency Exacerbates Colonic Inflammation Due to Activation of the Local Renin-Angiotensin System in the Colon.Digestive diseases and sciences · 2021Article
- Article
- Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD?Journal of clinical medicine · 2020Article
- Vitamin D, Autoimmune Disease and Rheumatoid Arthritis.Calcified tissue international · 2020Review
- The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD.Nutrients · 2019Article
- Managing vitamin D deficiency in inflammatory bowel disease.Frontline gastroenterology · 2019Review
- Vitamin D Deficiency in a Portuguese Cohort of Patients with Inflammatory Bowel Disease: Prevalence and Relation to Disease Activity.GE Portuguese journal of gastroenterology · 2019Article
- The effect of vitamin D administration on inflammatory markers in patients with inflammatory bowel disease.Intestinal research · 2019Article
- Seasonal variability of vitamin D status in patients with inflammatory bowel disease - A retrospective cohort study.PloS one · 2019Article
- Single high-dose oral vitamin D3 treatment in New Zealand children with inflammatory bowel disease.Translational pediatrics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVitamin D deficiency is common in patients with Crohn's disease (CD), although whether this impairs immune responsiveness, and is related to disease activity per se, remains unclear. We sought to investigate vitamin D pathways in patients with CD according to measures of inflammation and immune response.
methodsProspectively collected samples of a well-characterized cohort of patients with CD were used to measure serum 25(OH)-vitamin D levels by enzyme-linked immunoassay. Related gene expression was determined by polymerase chain reaction in T cells. The effect of vitamin D on the proliferation of isolated CD4 cells was determined.
resultsPatients with active CD had lower serum vitamin D levels than those in clinical remission; this measurement was independent of season or reported use of vitamin D supplements. Harvey-Bradshaw Index scores, but not C-reactive protein, correlated with serum vitamin D levels. Gene expression of the vitamin D receptor was higher in peripheral blood T cells from patients with active disease than in those in remission. The proportion of CD25hi CD4 cells from patients with CD increased in the presence of vitamin D. After treatment with infliximab, significant increases in serum vitamin D levels were noted in patients.
conclusionsLow vitamin D levels are associated with disease activity in CD and increase after infliximab treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.