ArticleThe Plant cell2014
Evolutionary origins of a bioactive peptide buried within Preproalbumin.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- The impact of CsPSKs on plant immunity: insights from a genome-wide study of small peptides in Citrus sinensis.Functional & integrative genomics · 2026Article
- Rational design of glycosaminoglycan binding cyclic peptides using cPEPmatch.Computational and structural biotechnology journal · 2024Article
- Plant peptides - redefining an area of ribosomally synthesized and post-translationally modified peptides.Natural product reports · 2024Review
- Mechanisms of protein evolution.Protein science : a publication of the Protein Society · 2022Review
- Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides.RSC chemical biology · 2021Article
- Plant derived cyclic peptides.Biochemical Society transactions · 2021Review
- Plant asparaginyl endopeptidases and their structural determinants of function.Biochemical Society transactions · 2021Review
- A chameleonic macrocyclic peptide with drug delivery applications.Chemical science · 2021Article
- Bowman-Birk Inhibitors: Insights into Family of Multifunctional Proteins and Peptides with Potential Therapeutical Applications.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides.Journal of industrial microbiology & biotechnology · 2020Review
- Progress toward sourcing plants for new bioconjugation tools: a screening evaluation of a model peptide ligase using a synthetic precursor.3 Biotech · 2019Article
- Peptide-based protease inhibitors from plants.Drug discovery today · 2019Review
- A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch.Plant direct · 2018Article
- Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.The Journal of biological chemistry · 2017Article
- Evidence for Ancient Origins of Bowman-Birk Inhibitors fromThe Plant cell · 2017Article
- A tripartite approach identifies the major sunflower seed albumins.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions.The Plant cell · 2015Review
- Proteolytic cleavage at twin arginine residues affects structural and functional transitions of lupin seed 11S storage globulin.PloS one · 2015Article
- Next generation sequencing and de novo transcriptomics to study gene evolution.Plant methods · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The de novo evolution of proteins is now considered a frequented route for biological innovation, but the genetic and biochemical processes that lead to each newly created protein are often poorly documented. The common sunflower (Helianthus annuus) contains the unusual gene PawS1 (Preproalbumin with SFTI-1) that encodes a precursor for seed storage albumin; however, in a region usually discarded during albumin maturation, its sequence is matured into SFTI-1, a protease-inhibiting cyclic peptide with a motif homologous to unrelated inhibitors from legumes, cereals, and frogs. To understand how PawS1 acquired this additional peptide with novel biochemical functionality, we cloned PawS1 genes and showed that this dual destiny is over 18 million years old. This new family of mostly backbone-cyclic peptides is structurally diverse, but the protease-inhibitory motif was restricted to peptides from sunflower and close relatives from its subtribe. We describe a widely distributed, potential evolutionary intermediate PawS-Like1 (PawL1), which is matured into storage albumin, but makes no stable peptide despite possessing residues essential for processing and cyclization from within PawS1. Using sequences we cloned, we retrodict the likely stepwise creation of PawS1's additional destiny within a simple albumin precursor. We propose that relaxed selection enabled SFTI-1 to evolve its inhibitor function by converging upon a successful sequence and structure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.