ArticleClinical immunology (Orlando, Fla.)
Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM).
Article in Clinical immunology (Orlando, Fla.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Peripheral immune profiles separate disease activity stages in birdshot uveitis.Frontiers in immunology · 2026Article
- Single-cell profiling identifies a CD8Nature communications · 2024Article
- EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders.Annals of the rheumatic diseases · 2023Review
- Pathogenic Role of IL-17 and Therapeutic Targeting of IL-17F in Psoriatic Arthritis and Spondyloarthropathies.International journal of molecular sciences · 2023Review
- The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases.Frontiers in immunology · 2023Review
- Analysis of peripheral inflammatory T cell subsets and their effector function in patients with Birdshot Retinochoroiditis.Scientific reports · 2021Article
- A comprehensive systematic review of CSF proteins and peptides that define Alzheimer's disease.Clinical proteomics · 2020Review
- MCAM/CD146 SignalingFrontiers in immunology · 2020Article
- CD146 T cells in lung cancer: its function, detection, and clinical implications as a biomarker and therapeutic target.Cancer cell international · 2019Review
- Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus.Journal of neuroinflammation · 2018Article
- Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy.Molecular & cellular proteomics : MCP · 2018Article
- High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis.Frontiers in immunology · 2018Article
- Circulating immune cells in multiple sclerosis.Clinical and experimental immunology · 2017Review
- Long Noncoding RNA uc001pwg.1 Is Downregulated in Neointima in Arteriovenous Fistulas and Mediates the Function of Endothelial Cells Derived from Pluripotent Stem Cells.Stem cells international · 2017Article
- Aberrant leukocyte telomere length in Birdshot Uveitis.PloS one · 2017Article
- Behçet's disease physiopathology: a contemporary review.Auto- immunity highlights · 2016Article
- Targeting soluble CD146 with a neutralizing antibody inhibits vascularization, growth and survival of CD146-positive tumors.Oncogene · 2016Article
- Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs.Journal of visualized experiments : JoVE · 2016Article
- Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment.Orphanet journal of rare diseases · 2016Review
- Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases.Autoimmunity reviews · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Interleukin-17 (IL-17) has been associated with the pathogenesis of numerous autoimmune diseases. CD4+ T cells secreting IL-17 are termed Th17 cells. CD8+ T cells, designated Tc17 cells, are also capable of secreting IL-17. Here we describe a population of Tc17 cells characterized by the expression of surface CD146, an endothelial adhesion molecule. These cells display signatures of a human Tc17 genotype and phenotype. Circulating CD8+CD146+ T cells are present in low levels in healthy adults. Elevations in CD8+CD146+ T cells are found in Behcet's disease and birdshot retinochoroidopathy, which have been reported to have HLA class I associations. Sarcoidosis does not have a class I association and displays an increase in CD4+ CD146+ T cells but not in CD8+CD146+ T cells. CD146 on these cells may facilitate their ability to bind to, and migrate through, endothelium, as has been reported for CD4+CD146+ T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.