Evidence map›Paper›PMID 24681206›Full record

ArticleGene expression patterns : GEP2014

Expression analysis of Dact1 in mice using a LacZ reporter.

Daisuke Suzuki, N Adrian Leu, Angela K Brice, Makoto Senoo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene expression patterns : GEP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daisuke SuzukiDepartment of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
N Adrian LeuDepartment of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Angela K BriceUniversity Laboratory Animal Resources, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Makoto SenooDepartment of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: msenoo@vet.upenn.edu.
University of Pennsylvania · USCalifornia Institute for Regenerative Medicine · US

Funding

Understanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2009 to 2013
$3.2M
NIAMS NIH HHS 5-P30-AR-057217NIAMS NIH HHS P30 AR057217
6 · The paper itself

Abstract

The Wnt signaling pathway is essential for cell fate decisions during embryonic development as well as for homeostasis after birth. Dapper antagonist of catenin-1 (Dact1) plays an important role during embryogenesis by regulating Wnt signaling pathways. Consequently, targeted disruption of the Dact1 gene in mice leads to perinatal lethality due to severe developmental defects involving the central nervous system, genitourinary system and distal digestive tract. However, the expression and potential function of Dact1 in other tissues during development and postnatal life have not been well studied. Here, we have generated reporter mice in which LacZ expression is driven by the Dact1 gene promoter and characterized Dact1-LacZ expression in embryos and adult tissues. Our data show that while Dact1-LacZ is expressed in multiple mesoderm- and neuroectoderm-derived tissues during development, high expression of Dact1-LacZ is restricted to a small subset of adult tissues, including the brain, eye, heart, and some reproductive organs. These results will serve as a basis for future investigation of Dact1 function in Wnt-mediated organogenesis and tissue homeostasis.

Indexed as

Lac OperonAnimalsEmbryo, MammalianFemaleGene Expression RegulationGenes, ReporterGenetic VectorsIntracellular Signaling Peptides and ProteinsMaleMiceOrgan SpecificityPromoter Regions, GeneticRNA-Binding Proteinsfrodo protein, mouseIntracellular Signaling Peptides and ProteinsRNA-Binding ProteinsDact1EmbryogenesisHomeostasisLacZ reporterWnt signal

Identifiers

PMID24681206
PMCPMC4426989
OpenAlexW2031600403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.