ReviewGastroenterology2014
Tissue engineering in the gut: developments in neuromusculature.
Review in Gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway.Frontiers in immunology · 2025Article
- Engineered muscle from micro-channeled PEG scaffold with magnetic FeMaterials today. Bio · 2023Article
- Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis.Bioactive materials · 2021Article
- Combating COVID-19 with tissue engineering: a review.Emergent materials · 2021Review
- Bi-layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue.Advanced functional materials · 2020Article
- Description of the unusual digestive tract ofPeerJ · 2020Article
- Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells.Journal of clinical medicine · 2019Article
- Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula.iScience · 2018Article
- Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.Nature communications · 2018Article
- Regenerative medicine for the esophagus.Surgery today · 2018Review
- Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype.International journal of molecular sciences · 2018Article
- IntestinalFrontiers in physiology · 2018Review
- Bioengineered intestinal muscularis complexes with long-term spontaneous and periodic contractions.PloS one · 2018Article
- The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform.Nature reviews. Gastroenterology & hepatology · 2017Review
- Regenerative medicine provides alternative strategies for the treatment of anal incontinence.International urogynecology journal · 2017Review
- Successful implantation of an engineered tubular neuromuscular tissue composed of human cells and chitosan scaffold.Surgery · 2015Article
- Expanding Two-Dimensional Electrospun Nanofiber Membranes in the Third Dimension By a Modified Gas-Foaming Technique.ACS biomaterials science & engineering · 2015Article
- Orthogonally oriented scaffolds with aligned fibers for engineering intestinal smooth muscle.Biomaterials · 2015Article
- The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes.Cell metabolism · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The complexity of the gastrointestinal (GI) tract lies in its anatomy as well as in its physiology. Several different cell types populate the GI tract, adding to the complexity of cell sourcing for regenerative medicine. Each cell layer has a specialized function in mediating digestion, absorption, secretion, motility, and excretion. Tissue engineering and regenerative medicine aim to regenerate the specific layers mimicking architecture and recapitulating function. Gastrointestinal motility is the underlying program that mediates the diverse functions of the intestines, as an organ. Hence, the first logical step in GI regenerative medicine is the reconstruction of the tubular smooth musculature along with the drivers of their input, the enteric nervous system. Recent advances in the field of GI tissue engineering have focused on the use of scaffolding biomaterials in combination with cells and bioactive factors. The ability to innervate the bioengineered muscle is a critical step to ensure proper functionality. Finally, in vivo studies are essential to evaluate implant integration with host tissue, survival, and functionality. In this review, we focus on the tubular structure of the GI tract, tools for innervation, and, finally, evaluation of in vivo strategies for GI replacements.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.