Evidence map›Paper›PMID 24681099›Full record

ArticleFEBS letters2014

Functional intersection of Human Defensin 5 with the TNF receptor pathway.

Wuyuan Lu, Erik de Leeuw

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Mechanisms and regulation of defensins in host defense.Signal transduction and targeted therapy · 2023
    Review
  2. Review
  3. Article
  4. Human Enteric Defensin 5 PromotesInfection and immunity · 2019
    Article
  5. Article
  6. JCI insight · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wuyuan LuInstitute of Human Virology, University of Maryland Baltimore School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
Erik de LeeuwInstitute of Human Virology, University of Maryland Baltimore School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA. Electronic address: edeleeuw@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Inhibition of Anthrax Lethal Factor by alpha-defensinsR01AI072732 · NIAID · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI LU, WUYUAN · 2007 to 2011
$2.4M
Molecular Basis of Human Neutrophil alpha-Defensin FunctionR01AI061482 · NIAID · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI LU, WUYUAN · 2005 to 2009
$1.8M
NIAID NIH HHS AI061482NIAID NIH HHS AI072732NIAID NIH HHS R01 AI061482NIAID NIH HHS R01 AI072732
6 · The paper itself

Abstract

Defensins are cationic antimicrobial peptides that contribute to regulation of host cell function also. Here, we report on the regulation of cell death by Human Defensin 5, the major antimicrobial peptide of ileal Paneth cells. We find that Human Defensin 5-mediated cellular effects depend on functional expression of Tumor Necrosis Factor receptors and downstream mediators of TNF signaling. Our data indicate the involvement of interactions between Human Defensin 5 and the extra-cellular domain of Tumor Necrosis Factor receptor 1. Human Defensin-5 also induces apoptosis intrinsically by targeting the mitochondrial membrane.

Indexed as

Signal Transductionalpha-DefensinsAnimalsApoptosisCaspase 8Cells, CulturedCell SurvivalDefensinsFlow CytometryHumansInterleukin-8Jurkat CellsMacrophagesMiceMice, KnockoutMicroscopy, Confocalalpha-DefensinsCaspase 8DEFA5 protein, humanDefensinsInterleukin-8Receptors, Tumor Necrosis Factor, Type IAntimicrobial peptideApoptosisHuman Defensin 5Interleukin 8TNF receptor

Identifiers

PMID24681099
PMCPMC5374975
OpenAlexW2069781093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.