Evidence map›Paper›PMID 24681081›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2014

Effects of Clostridium difficile infection in patients with alcoholic hepatitis.

Vinay Sundaram, Folasade P May, Vignan Manne, Sammy Saab

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Infections in Alcoholic Hepatitis.Journal of clinical and translational hepatology · 2022
    Review
  2. The Risk ofMedicina (Kaunas, Lithuania) · 2021
    Article
  3. World journal of hepatology · 2021
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Infections in severe alcoholic hepatitis.Annals of gastroenterology · 2017
    Review
  10. Article
  11. Clostridium difficile infection in patients with liver disease: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vinay SundaramDivision of Gastroenterology and Hepatology and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: vinay.sundaram@cshs.org.
Folasade P MayDepartment of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; Department of Health Policy and Management, University of California at Los Angeles Fielding School of Public Health, University of California at Los Angeles, Los Angeles, California.
Vignan ManneDepartment of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
Sammy SaabDepartment of Medicine and Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
NIDDK NIH HHS T32 DK007180NIDDK NIH HHS T32DK07180-34
6 · The paper itself

Abstract

BACKGROUND &

aimsInfection increases mortality in patients with alcoholic hepatitis (AH). Little is known about the association between Clostridium difficile infection (CDI) and AH. We examined the prevalence and effects of CDI in patients with AH, compared with those of other infections.

methodsWe performed a cross-sectional analysis using data collected from the Nationwide Inpatient Sample, from 2008 through 2011. International Classification of Diseases, 9th revision, Clinical Modification codes were used to identify patients with AH. We used multivariable logistic regression to determine risk factors that affect mortality, negative binomial regression to evaluate the effects of CDI on predicted length of stay (LOS), and Poisson regression to determine the effects of CDI on predicted hospital charges. Chi-square and Wilcoxon rank-sum analyses were used to compare mortality, LOS, and hospital charges associated with CDI with those associated with urinary tract infection (UTI) and spontaneous bacterial peritonitis (SBP).

resultsOf 10,939 patients with AH, 177 had CDI (1.62%). Patients with AH and CDI had increased odds of inpatient mortality (adjusted odds ratio, 1.75; P = .04), a longer predicted LOS (10.63 vs 5.75 d; P < .001), and greater predicted hospital charges ($36,924.30 vs $29,136.58; P < .001), compared with those without CDI. Compared with UTI, CDI was associated with similar mortality but greater LOS (9 vs 6 d; P < .001) and hospital charges ($45,607 vs $32,087; P < .001). SBP was associated with higher mortality than CDI (17.3% vs 10.1%; P = .045), but similar LOS and hospital charges.

conclusionsIn patients with AH, CDI is associated with greater mortality and health care use. These effects appear similar to those for UTI and SBP. We propose further studies to determine the cost effectiveness of screening for CDI among patients with AH.

Indexed as

AdolescentAdultAgedAged, 80 and overClostridioides difficileClostridium InfectionsCross-Sectional StudiesFemaleHepatitis, AlcoholicHospital ChargesHumansLength of StayMaleMiddle AgedModels, StatisticalPrevalenceAlcoholic Liver DiseaseDatabaseICD-9-CMNIS

Identifiers

PMID24681081
PMCPMC4171202
OpenAlexW2067209891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.