ArticleOsteoarthritis and cartilage2014
Cigarette smoking and risk of total knee replacement for severe osteoarthritis among Chinese in Singapore--the Singapore Chinese health study.
Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Association of smoking with knee osteoarthritis structural defects and symptoms: an individual participant data meta-analysis.Scientific reports · 2024Pooled it
- Impact of smoking on the incidence and post-operative complications of total knee arthroplasty: A systematic review and meta-analysis of cohort studies.Bosnian journal of basic medical sciences · 2022Pooled it
- Smoking quitting promotes neuromuscular and cartilage recovery in knee osteoarthritis.European journal of applied physiology · 2026Article
- Expectation fulfillment is associated with good outcomes and patient satisfaction after knee arthroplasty: a prospective study in a multi-ethnic Asian population.Scientific reports · 2025Article
- Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003-2016.Scientific reports · 2025Article
- Association of smoking with cartilage loss of knee osteoarthritis: data from two longitudinal cohorts.BMC musculoskeletal disorders · 2023Article
- Association of smoking and osteoarthritis in US (NHANES 1999-2018).Scientific reports · 2023Article
- Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study.RMD open · 2021Article
- Measurement properties of Pain Catastrophizing Scale in patients with knee osteoarthritis.Clinical rheumatology · 2021Article
- A comparison of risk factors for osteo- and rheumatoid arthritis using NHANES data.Preventive medicine reports · 2020Article
- Developing prediction models for total knee replacement surgery in patients with osteoarthritis: Statistical analysis plan.Osteoarthritis and cartilage open · 2020Article
- Article
- Intergenerational differences in smoking among West Indian, Haitian, Latin American, and African blacks in the United States.SSM - population health · 2017Article
- The Prevalence, Incidence, and Progression of Hand Osteoarthritis in Relation to Body Mass Index, Smoking, and Alcohol Consumption.The Journal of rheumatology · 2017Article
- Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study.Scientific reports · 2017Article
- Article
- The relationship between the presence of depressive symptoms and the severity of self-reported knee pain in the middle aged and elderly.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Article
- Article
- The relationship between smoking and knee osteoarthritis in the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2016Article
- Association between direct and indirect smoking and osteoarthritis prevalence in Koreans: a cross-sectional study.BMJ open · 2016Article
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6 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeData on the effects of cigarette smoking with osteoarthritis (OA) are inconsistent and no study has examined the effect of smoking cessation. We examined smoking status, duration, dosage and cessation in association with risk of total knee replacement (TKR) for severe knee OA among elderly Chinese in Singapore.
methodsWe used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63,257 Chinese men and women aged 45-74 years during enrollment between 1993 and 1998. Detailed information on smoking, current diet and lifestyle factors were obtained through in person interviews. As of 31 December 2011, 1,973 incident TKR cases for severe knee OA had been identified via linkage with nationwide hospital discharge database. We used Cox regression methods to examine smoking in relation to TKR risk with adjustment for age, gender, education, body mass index (BMI), comorbidities and physical activity level.
resultsCompared to never smokers, current smokers had a 51% decrease in risk of TKR [Hazards ratio (HR) = 0.49; 95% confidence interval (CI) = 0.40-0.60]. Among current smokers, there was a very strong dose-dependent association between increasing duration and dosage of smoking with decreasing risk of TKR (P for trend <0.0001). Among former smokers, there was a dose-dependent response between decrease in duration of smoking cessation and reduction in TKR risk (P for trend = 0.034).
conclusionOur findings strongly implicate smoking as a protective factor for TKR indicated for severe knee OA. This concurs with experimental data that nicotine promotes proliferation and collagen synthesis in chondrocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.