Evidence map›Paper›PMID 24680862›Full record

ArticleMicrobes and infection2014

Clearance of Pneumocystis murina infection is not dependent on MyD88.

Chiara Ripamonti, Lisa R Bishop, Jun Yang, Richard A Lempicki, Joseph A Kovacs

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbes and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Targeting β-glucans, vital components of theFrontiers in immunology · 2023
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chiara RipamontiCritical Care Medicine Department, NIH Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892-1662, USA.
Lisa R BishopCritical Care Medicine Department, NIH Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892-1662, USA.
Jun YangLaboratory of Immunopathogenesis and Bioinformatics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Richard A LempickiLaboratory of Immunopathogenesis and Bioinformatics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Joseph A KovacsCritical Care Medicine Department, NIH Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892-1662, USA. Electronic address: jkovacs@mail.nih.gov.
National Institutes of Health Clinical Center · USFrederick National Laboratory for Cancer Research · USLeidos (United States) · US

Funding

Characterization Of Immune Responses During Pneumocystis PneumoniaZIACL000146 · CLC · CLINICAL CENTER · PI KOVACS, JOSEPH A · 2009 to 2025
$0k
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA CL000146NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

To determine if myeloid differentiation factor 88 (MyD88), which is necessary for signaling by most TLRs and IL-1Rs, is necessary for control of Pneumocystis infection, MyD88-deficient and wild-type mice were infected with Pneumocystis by exposure to infected seeder mice and were followed for up to 106 days. MyD88-deficient mice showed clearance of Pneumocystis and development of anti-Pneumocystis antibody responses with kinetics similar to wild-type mice. Based on expression levels of select genes, MyD88-deficient mice developed immune responses similar to wild-type mice. Thus, MyD88 and the upstream pathways that rely on MyD88 signaling are not required for control of Pneumocystis infection.

Indexed as

Signal TransductionAnimalsMiceMice, Inbred C57BLMyeloid Differentiation Factor 88PneumocystisPneumocystis InfectionsReceptors, Interleukin-1Myeloid Differentiation Factor 88Receptors, Interleukin-1Innate immunityMyD88PCPPneumocystisTLR

Identifiers

PMID24680862
PMCPMC4071138
OpenAlexW2076306385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.