ReviewMethods (San Diego, Calif.)2014
Strategies for exploring TGF-β signaling in Drosophila.
Review in Methods (San Diego, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Article
- Mutations in TGF-beta signaling pathway components regulate themicroPublication biology · 2024Article
- TGF-β Type II Receptor Punt Suppresses Antimicrobial Peptide Expression and Influences Development inInsects · 2023Article
- Functional role of the TGF-β signaling in theCurrent research in immunology · 2023Review
- A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.PLoS biology · 2022Article
- pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.The Journal of cell biology · 2022Article
- Application of the 3C Method to Study the Developmental Genes inFrontiers in genetics · 2022Article
- activin-2 is required for regeneration of polarity on the planarian anterior-posterior axis.PLoS genetics · 2021Article
- Muscle-derived Myoglianin regulateseLife · 2020Article
- TheMicroorganisms · 2020Article
- Transcript analysis reveals the involvement of NF-κB transcription factors for the activation of TGF-β signaling in nematode-infected Drosophila.Immunogenetics · 2019Article
- TGF-β Signaling Interferes With theFrontiers in physiology · 2019Article
- Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons.Cell reports · 2018Article
- Transcriptional up-regulation of the TGF-β intracellular signaling transducer Mad of Drosophila larvae in response to parasitic nematode infection.Innate immunity · 2018Article
- Regulation of neuroblast proliferation by surface glia in the Drosophila larval brain.Scientific reports · 2018Article
- Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.BMC genomics · 2017Article
- Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochasticeLife · 2017Article
- TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster.Immunobiology · 2016Article
- Ubx dynamically regulates Dpp signaling by repressing Dad expression during copper cell regeneration in the adult Drosophila midgut.Developmental biology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The TGF-β pathway is an evolutionarily conserved signal transduction module that mediates diverse biological processes in animals. In Drosophila, both the BMP and Activin branches are required for viability. Studies rooted in classical and molecular genetic approaches continue to uncover new developmental roles for TGF-β signaling. We present an overview of the secreted ligands, transmembrane receptors and cellular Smad transducer proteins that compose the core pathway in Drosophila. An assortment of tools have been developed to conduct tissue-specific loss- and gain-of-function experiments for these pathway components. We discuss the deployment of these reagents, with an emphasis on appropriate usage and limitations of the available tools. Throughout, we note reagents that are in need of further improvement or development, and signaling features requiring further study. A general theme is that comparison of phenotypes for ligands, receptors, and Smads can be used to map tissue interactions, and to separate canonical and non-canonical signaling activities. Core TGF-β signaling components are subject to multiple layers of regulation, and are coupled to context-specific inputs and outputs. In addition to fleshing out how TGF-β signaling serves the fruit fly, we anticipate that future studies will uncover new regulatory nodes and modes and will continue to advance paradigms for how TGF-β signaling regulates general developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.