Evidence map›Paper›PMID 24680584›Full record

ArticleGynecologic oncology2014

Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: results from the Women's Health Initiative.

Yang Zhou, Rowan Chlebowski, Michael J LaMonte, Jennifer W Bea, Lihong Qi, Robert Wallace, Sayeh Lavasani, Brian W Walsh, Garnet Anderson, Mara Vitolins and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Barriers and facilitators of exercise experienced by cancer survivors: a mixed methods systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  3. Association between Body Mass Index and Cancer Survival in a Pooled Analysis of 22 Clinical Trials.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
    Pooled it
  4. Effect of exercise on body composition among women with ovarian cancer.Journal of cancer survivorship : research and practice · 2023
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  14. Association of prognostic nutritional index with muscle loss and survival in patients with ovarian cancer treated with primary debulking surgery and chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  15. Epidemiological trends and risk factors of gynecological cancers: an update.Medical oncology (Northwood, London, England) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang ZhouDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. Electronic address: yang.zhou@yale.edu.
Rowan ChlebowskiDavid Geffen School of Medicine, University of California, Los Angeles, Torrance, CA, USA.
Michael J LaMonteDepartment of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, NY, USA.
Jennifer W BeaUniversity of Arizona Cancer Center, Tucson, AZ, USA.
Lihong QiDivision of Biostatistics, School of Medicine, University of California, Davis, CA, USA.
Robert WallaceDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Sayeh LavasaniBarbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Brian W WalshCenter for Reproductive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Garnet AndersonSchool of Public Health, University of Washington, Seattle, WA, USA.
Mara VitolinsPublic Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Gloria SartoDepartment of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Melinda L IrwinDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundOvarian cancer is often diagnosed at late stages and consequently the 5-year survival rate is only 44%. However, there is limited knowledge of the association of modifiable lifestyle factors, such as physical activity and obesity on mortality among women diagnosed with ovarian cancer. The purpose of our study was to prospectively investigate the association of (1) measured body mass index (BMI), and (2) self-reported physical activity with ovarian cancer-specific and all-cause mortality in postmenopausal women enrolled in the Women's Health Initiative (WHI).

methodsParticipants were 600 women diagnosed with primary ovarian cancer subsequent to enrollment in WHI. Exposure data, including measured height and weight and reported physical activity from recreation and walking, used in this analysis were ascertained at the baseline visit for the WHI. Cox proportional hazard regression was used to examine the associations between BMI, physical activity and mortality endpoints.

resultsVigorous-intensity physical activity was associated with a 26% lower risk of ovarian cancer specific-mortality (HR=0.74; 95% CI: 0.56-0.98) and a 24% lower risk of all-cause mortality (HR=0.76; 95% CI: 0.58-0.98) compared to no vigorous-intensity physical activity. BMI was not associated with mortality.

conclusionsParticipating in vigorous-intensity physical activity, assessed prior to ovarian cancer diagnosis, appears to be associated with a lower risk of ovarian cancer mortality.

Indexed as

ExerciseMotor ActivityAgedBody Mass IndexCause of DeathCohort StudiesFemaleHumansMiddle AgedObesityOvarian NeoplasmsOverweightProportional Hazards ModelsProspective StudiesRisk FactorsExerciseMortalityObesityOvarian cancerPhysical activityWeight

Identifiers

PMID24680584
PMCPMC4064800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.