ReviewJournal of the International AIDS Society2014
HIV pre-exposure prophylaxis for people who inject drugs: a review of current results and an agenda for future research.
Review in Journal of the International AIDS Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Systematic review of HIV treatment adherence research among people who inject drugs in the United States and Canada: evidence to inform pre-exposure prophylaxis (PrEP) adherence interventions.BMC public health · 2019Pooled it
- Development and Validation of a Provider-Specific Anticipated Stigma Scale for People Who Inject Drugs.AIDS and behavior · 2026Article
- PrEP attitudes, willingness, and preferences among men incarcerated in jail in Massachusetts.BMC public health · 2025Article
- Patient and Provider Perspectives on a Novel, Low-Threshold HIV PrEP Program for People Who Inject Drugs Experiencing Homelessness.Journal of general internal medicine · 2023Article
- Qualitative inquiry into perceptions of HIV pre-exposure prophylaxis among people who inject drugs living with hepatitis C in Seattle, WA, USA.Harm reduction journal · 2022Article
- Acceptability of injectable pre-exposure prophylaxis among people who inject drugs in three urban U.S. settings.BMC infectious diseases · 2022Article
- PrEP for key populations: results from the first PrEP demonstration project in the Democratic Republic of the Congo.AIDS care · 2022Article
- Knowledge and Use of PEP and PrEP Among Key Populations Tested in Community Centers in Portugal.Frontiers in public health · 2021Article
- HIV Pre-exposure Prophylaxis for People Who Inject Drugs: The Context of Co-occurring Injection- and Sexual-Related HIV Risk in the U.S. Northeast.Substance use & misuse · 2020Article
- Responding to global stimulant use: challenges and opportunities.Lancet (London, England) · 2019Review
- A missing perspective: injectable pre-exposure prophylaxis for people who inject drugs.AIDS care · 2019Article
- Optimizing HIV prevention and treatment outcomes for persons with substance use in Central Asia: what will it take?Current opinion in HIV and AIDS · 2019Review
- Medical Providers and Harm Reduction Views on Pre-Exposure Prophylaxis for HIV Prevention Among People Who Inject Drugs.AIDS education and prevention : official publication of the International Society for AIDS Education · 2019Article
- Limited Knowledge and Mixed Interest in Pre-Exposure Prophylaxis for HIV Prevention Among People Who Inject Drugs.AIDS patient care and STDs · 2018Article
- Perspectives on HIV pre-exposure prophylaxis (PrEP) utilization and related intervention needs among people who inject drugs.Harm reduction journal · 2018Article
- Continued Transmission of HIV Among Young Adults Who Inject Drugs in San Francisco: Still Room for Improvement.AIDS and behavior · 2018Article
- Observational
- Awareness of pre-exposure prophylaxis (PrEP) among women who inject drugs in NYC: the importance of networks and syringe exchange programs for HIV prevention.Harm reduction journal · 2017Article
- Primary Care Physicians' Willingness to Prescribe HIV Pre-exposure Prophylaxis for People who Inject Drugs.AIDS and behavior · 2017Article
- Update on the Epidemiology and Prevention of HIV/AIDS in the United States.Current epidemiology reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionStudies examining the use of pre-exposure prophylaxis (PrEP) to prevent HIV transmission among people who inject drugs (PWIDs) have not been adequately summarized. Recently, the Bangkok Tenofovir Study has shown that PrEP may be effective at reducing new HIV infections among this high-risk group. This randomized controlled trial was the first study to specifically examine the efficacy of PrEP among PWIDs. In this review, we present the current state of evidence regarding the use of PrEP to prevent HIV infection in PWID populations, and set an agenda for future research to inform the most effective implementation of PrEP in the context of existing evidence-based HIV prevention strategies. DISCUSSION: Despite positive trial results confirming that PrEP may prevent HIV transmission among PWIDs, there remain many questions regarding the interpretation of these results, as well as obstacles to the implementation of PrEP regimens within highly diverse drug-using communities. Aside from the Bangkok Tenofovir Study, we identified only one other published study that has collected empirical data to inform the use of PrEP among PWIDs. The large gap in research regarding the use and implementation of PrEP for PWIDs signals the need for further research and attention.
conclusionsWe recommend that future research efforts focus on elucidating the generalizability of the Bangkok Tenofovir Study results in other injection drug-using populations, examining the willingness of PWIDs to use PrEP in diverse contexts, identifying barriers to adherence to PrEP regimens and determining the most effective ways to implement PrEP programmes within the context of existing evidence-based prevention strategies, including opioid substitution therapy and needle and syringe distribution programmes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.