Evidence map›Paper›PMID 24679532›Full record

ReviewCell2014

The virome in mammalian physiology and disease.

Herbert W Virgin

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 325 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
325citing papers in PubMed, 2 pooled it
30.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

325 citing papers in PubMed, 2 syntheses or guidelines pooled it, 591 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Gut virome dynamics: from commensal to critical player in health and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  13. Article
  14. Article
  15. Importance of human microbiome: an update.Frontiers in microbiomes · 2026
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

265 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: virgin@wustl.edu.
Washington University in St. Louis · US

Funding

Virology and Smallpox VaccinationsU54AI057160 · NIAID · WASHINGTON UNIVERSITY · PI RAY, RANJIT · 2003 to 2013
$80.9M
IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUSR01AI054483 · NIAID · WASHINGTON UNIVERSITY · PI VIRGIN, HERBERT W · 2003 to 2012
$3.7M
METAGENOMICS OF ENTERIC DISEASE IN SIV-INFECTED AND UNINFECTED MACAQUESR01OD011170 · OD · WASHINGTON UNIVERSITY · PI BAROUCH, DAN H., VIRGIN, HERBERT W · 2012 to 2014
$2.3M
SUSCEPTIBILILTY GENE-VIRUS INTERACTIONS IN INFLAMMATORY BOWEL DISEASER01AI084887 · NIAID · WASHINGTON UNIVERSITY · PI STAPPENBECK, THADDEUS S, VIRGIN, HERBERT W · 2010 to 2014
$1.9M
NIAID NIH HHS AI054483NIAID NIH HHS AI084887NIAID NIH HHS R01 AI054483NIAID NIH HHS R01 AI084887NIAID NIH HHS U54 AI057160NIH HHS R01 OD011170
6 · The paper itself

Abstract

The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease.

Indexed as

MicrobiotaAnimalsBacteriaBacteriophagesHost-Pathogen InteractionsHumansMammalsViruses

Identifiers

PMID24679532
PMCPMC3977141
OpenAlexW2015035889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.