ReviewCell2014
Transgenerational epigenetic inheritance: myths and mechanisms.
Review in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 756 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
756 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,811 citations in OpenAlex.
- Role of histone deacetylases and sirtuins in the ischaemic stroke: a systematic review and meta-analysis of animal studies.Stroke and vascular neurology · 2026Pooled it
- Impact of parental adverse childhood experiences on children's healthcare utilisation: a systematic review.Journal of epidemiology and community health · 2026Pooled it
- Transgenerational consequences of grandparents' smoking on grandchildren's development: a systematic review.BMJ open · 2025Pooled it
- Conserved sex-biased DNA methylation patterns target key developmental genes and reproductive function in two Poeciliidae species.G3 (Bethesda, Md.) · 2026Article
- Methylated memories mechanism, evidence, and skepticism in plant transgenerational epigenetic inheritance.Protoplasma · 2026Review
- Sex-biased metabolic programming in Drosophila via paternal white rice exposure.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- The crucible of resilience: hormesis as the unifying principle of evolution, genetics, and epigenetics.Archives of toxicology · 2026Review
- Genome wide transcriptional changes underlie gradual and recurrent adaptation to protein malnutrition in zebrafish.PLoS genetics · 2026Article
- Comparative transcriptomics reveals epigenetic and transcriptional regulatory genes associated with drought stress memory in winter wheat.Journal of experimental botany · 2026Article
- Review
- Transmission of an environmental modification in quails across three generations: changes in the contribution to phenotypic variability.Genetics, selection, evolution : GSE · 2026Article
- Partial Reproducibility and Pleiotropic Epigenetic QTLs inPlants (Basel, Switzerland) · 2026Article
- Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.Plant biology (Stuttgart, Germany) · 2026Article
- Paracetamol Responses Depend on Temperature, Life Stage, and Genetic Background inMedicines (Basel, Switzerland) · 2026Article
- Review
- Epigenetic Control of Cold Stress Tolerance in Plants: Emerging Mechanisms and Applications for Crop Improvement.International journal of molecular sciences · 2026Review
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.Molecular genetics and genomics : MGG · 2026Article
- Premeiotic chromatin states orchestrate gene expression during male gametogenesis in rice.Genome biology · 2026Article
696 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Since the human genome was sequenced, the term "epigenetics" is increasingly being associated with the hope that we are more than just the sum of our genes. Might what we eat, the air we breathe, or even the emotions we feel influence not only our genes but those of descendants? The environment can certainly influence gene expression and can lead to disease, but transgenerational consequences are another matter. Although the inheritance of epigenetic characters can certainly occur-particularly in plants-how much is due to the environment and the extent to which it happens in humans remain unclear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.