ArticleChiropractic & manual therapies2014
Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskeletal conditions: systematic review and update of UK evidence report.
Article in Chiropractic & manual therapies, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 74 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MERCI Chronic Pain Research Clinic (Medical Education and Research in Compassionate Integration/Intervention)
Autonomic Recalibration Approach to Myofascial Pain Elimination
The Impact of Myofascial Therapy on Connective Tissue
Who cites it
74 citing papers in PubMed, 12 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Non-pharmacological interventions for improving sleep in people living with HIV: a systematic narrative review.Frontiers in neurology · 2023Pooled it
- The global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature.Chiropractic & manual therapies · 2021Pooled it
- Do manual therapies have a specific autonomic effect? An overview of systematic reviews.PloS one · 2021Pooled it
- Comparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines.BMJ open · 2020Pooled it
- Manual therapy for the pediatric population: a systematic review.BMC complementary and alternative medicine · 2019Pooled it
- The acute effects of joint manipulative techniques on markers of autonomic nervous system activity: a systematic review and meta-analysis of randomized sham-controlled trials.Chiropractic & manual therapies · 2019Pooled it
- Unravelling functional neurology: does spinal manipulation have an effect on the brain? - a systematic literature review.Chiropractic & manual therapies · 2019Pooled it
- Manual therapy for unsettled, distressed and excessively crying infants: a systematic review and meta-analyses.BMJ open · 2018Pooled it
- The risk associated with spinal manipulation: an overview of reviews.Systematic reviews · 2017Pooled it
- The Use of Spinal Manipulative Therapy in the Management of Chronic Obstructive Pulmonary Disease: A Systematic Review.Journal of alternative and complementary medicine (New York, N.Y.) · 2016Pooled it
- Manipulation and mobilisation for neck pain contrasted against an inactive control or another active treatment.The Cochrane database of systematic reviews · 2015Pooled it
- Exercises for mechanical neck disorders.The Cochrane database of systematic reviews · 2015Pooled it
- Comfort during side posture lumbopelvic manipulation in a low back pain population-effects of a typical versus modified flexed lumbopelvic position: a crossover randomized control trial.Chiropractic & manual therapies · 2025Trial
- Comparison of Outcomes of Physical Therapy Exercises Combined with Either a Video-Based Smartphone Application System or a Written Exercise Program Handout in 34 Patients with Non-Specific Neck Pain.Medical science monitor : international medical journal of experimental and clinical research · 2024Trial
- Potential effect modifiers for treatment with chiropractic manipulation versus sham manipulation for recurrent headaches in children aged 7-14 years: development of and results from a secondary analysis of a randomised clinical trial.Chiropractic & manual therapies · 2023Trial
- The effect of cervical mobilization on balance and static plantar loading distribution in patients with multiple sclerosis: A randomized crossover study.Neurosciences (Riyadh, Saudi Arabia) · 2022Trial
- Effectiveness of chiropractic manipulation versus sham manipulation for recurrent headaches in children aged 7-14 years - a randomised clinical trial.Chiropractic & manual therapies · 2021Trial
- Dose-response and efficacy of spinal manipulation for care of cervicogenic headache: a dual-center randomized controlled trial.The spine journal : official journal of the North American Spine Society · 2018Trial
- Assessing the impact of manual therapy in the management of nonspecific low back pain: a scoping review of the outcomes used in clinical trials.BMC complementary medicine and therapies · 2026Article
- Force variability of thoracic spine mobilization and manipulation delivered by experienced physiotherapists to healthy human volunteers and a manikin: an observational study.Chiropractic & manual therapies · 2025Observational
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis systematic review updated and extended the "UK evidence report" by Bronfort et al. (Chiropr Osteopath 18:3, 2010) with respect to conditions/interventions that received an 'inconclusive' or 'negative' evidence rating or were not covered in the report.
methodsA literature search of more than 10 general medical and specialised databases was conducted in August 2011 and updated in March 2013. Systematic reviews, primary comparative studies and qualitative studies of patients with musculoskeletal or non-musculoskeletal conditions treated with manual therapy and reporting clinical outcomes were included. Study quality was assessed using standardised instruments, studies were summarised, and the results were compared against the evidence ratings of Bronfort. These were either confirmed, updated, or new categories not assessed by Bronfort were added.
results25,539 records were found; 178 new and additional studies were identified, of which 72 were systematic reviews, 96 were randomised controlled trials, and 10 were non-randomised primary studies. Most 'inconclusive' or 'moderate' evidence ratings of the UK evidence report were confirmed. Evidence ratings changed in a positive direction from inconclusive to moderate evidence ratings in only three cases (manipulation/mobilisation [with exercise] for rotator cuff disorder; spinal mobilisation for cervicogenic headache; and mobilisation for miscellaneous headache). In addition, evidence was identified on a large number of non-musculoskeletal conditions not previously considered; most of this evidence was rated as inconclusive.
conclusionsOverall, there was limited high quality evidence for the effectiveness of manual therapy. Most reviewed evidence was of low to moderate quality and inconsistent due to substantial methodological and clinical diversity. Areas requiring further research are highlighted.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.