ArticleThe Journal of clinical investigation1989
Granulocyte-macrophage colony-stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 190 citations in OpenAlex.
- Long-term patient reported outcomes and hematologic toxicity among patients who received Granulocyte-Colony Stimulating Factors during chemotherapy for early breast cancer.Breast (Edinburgh, Scotland) · 2021Article
- The role of granulocyte colony‑stimulating factor in breast cancer development: A review.Molecular medicine reports · 2020Review
- Inflammation and skeletal metastasis.BoneKEy reports · 2015Review
- Bacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism.PloS one · 2014Article
- Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity.Seminars in immunopathology · 2013Review
- Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.Investigative ophthalmology & visual science · 2012Article
- Spontaneous and induced osteoclastogenic behaviour of human peripheral blood mononuclear cells and their CD14(+) and CD14(-) cell fractions.Cell proliferation · 2011Article
- Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.Arthritis and rheumatism · 2010Article
- Carrageenan primes leukocytes to enhance lipopolysaccharide-induced tumor necrosis factor alpha production.Infection and immunity · 1999Article
- Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis.Annals of the rheumatic diseases · 1999Article
- Effects of anticoagulants and temperature on expression of activation markers CD11b and HLA-DR on human leukocytes.Clinical and diagnostic laboratory immunology · 1998Article
- Differential production of chemokines by phagocytosing rat neutrophils and macrophages.Inflammation · 1998Article
- Granulocyte-macrophage colony-stimulating factor in Staphylococcus aureus-induced arthritis.Infection and immunity · 1998Article
- Article
- Anti-tumoral effect of GM-CSF with or without cytokines and monoclonal antibodies in solid tumors.Medical oncology (Northwood, London, England) · 1996Review
- Granulocyte-colony stimulating factor produced by pancreatic carcinoma.International journal of pancreatology : official journal of the International Association of Pancreatology · 1996Article
- Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation.Mediators of inflammation · 1996Article
- Interleukin-1 expression by neutrophils in rheumatoid arthritis.Annals of the rheumatic diseases · 1995Article
- Neutrophil-mediated tissue injury and its modulation.Intensive care medicine · 1995Review
- Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice.The Journal of clinical investigation · 1994Article
Corrections and comments
- Retraction · 1998-07-01Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by Third Party · Notice - Limited or No Information · Objections by Third Party ·
- Retracted
- RetractedRetraction.2003
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known as an inducer of proliferation and functional activation of myeloid cells. This study was carried out to characterize the effects of GM-CSF on polymorphonuclear leukocytes (PMN) more extensively. Using Northern blot analysis, we show that PMN are able to accumulate mRNAs for different cytokines, including tumor necrosis factor-alpha (TNF-alpha); G-CSF, and M-CSF, all of which are involved in inflammation and hematopoiesis. Biological assays and immunoassays demonstrate that PMN translate these mRNAs, except TNF-alpha, into secretory proteins. However, the expression of these cytokines is dependent on stimulation by exogenous signals, preferentially provided by the T cell-derived lymphokine GM-CSF. Stimulation of hematopoiesis and amplification of defense mechanisms after T cell activation thus might involve not only monocytes but also PMN, a cell type previously believed to be biosynthetically inactive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.