Evidence map›Paper›PMID 24679069›Full record

ArticleThe World Allergy Organization journal2014

Sublingual immunotherapy: World Allergy Organization position paper 2013 update.

Giorgio Walter Canonica, Linda Cox, Ruby Pawankar, Carlos E Baena-Cagnani, Michael Blaiss, Sergio Bonini, Jean Bousquet, Moises Calderón, Enrico Compalati, Stephen R Durham and 15 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05570383 (Observation on the Efficacy of Sublingual Immunotherapy With Dust Mite Allergen for Perennial Allergic Rhinitis and the Mechanism of Action on ILCs With ILC1s and ILC2s and ILC3s), which is not on this map. Cited by 168 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05570383 phase2 / phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

Observation on the Efficacy of Sublingual Immunotherapy With Dust Mite Allergen for Perennial Allergic Rhinitis and the Mechanism of Action on ILCs With ILC1s and ILC2s and ILC3s

TypeinterventionalSponsorPeople's Hospital of Anshun City of Guizhou ProvinceRan2022 to 2024Enrolled60ConditionsAllergic RhinitisArmsDust mite drops (trade name: Changdi, Zhejiang Tawu Biotechnology Co. Ltd.).
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Ragweed sublingual immunotherapy (SLIT) tablets in allergic rhinoconjunctivitis: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  3. Sublingual immunotherapy for asthma.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Sublingual immunotherapy for asthma.The Cochrane database of systematic reviews · 2015
    Pooled it
  5. Pooled it
  6. Trial
  7. Corticosteroids sparing effect of artemisia annua sublingual immunotherapy: A prospective study in pediatric seasonal allergic rhinoconjunctivitis (INCs sparing and efficacy of Artemisia annua SLIT in pediatric SARC).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Trial
  8. Trial
  9. Trial
  10. Single-allergen sublingual immunotherapy versus multi-allergen subcutaneous immunotherapy for children with allergic rhinitis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Review
  15. Article
  16. Article
  17. Review
  18. Effect of initiation treatment timing on efficacy ofThe World Allergy Organization journal · 2026
    Article
  19. Summarizing the 2024 immunotherapy manual of the Canadian society of allergy and clinical immunology.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Review
  20. Review

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Giorgio Walter Canonica *Respiratory and Allergy Clinic, DIMI-Department of Internal Medicine, University of Genoa, IRCCS Aou San Martino, Largo Rosanna Benzi 10, Genoa 1-16132, Italy.
Linda Cox *Department of Medicine, Nova Southeastern University, College of Osteopathic Medicine, Davie Florida, USA.
Ruby Pawankar *Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
Carlos E Baena-CagnaniResearch Center for Respiratory Medicine (CIMER), Catholic University, Fundación LIBRA, Córdoba, Argentina.
Michael BlaissDepartment of Pediatrics and Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Sergio BoniniDepartment of Medicine, Second University of Naples, Institute of Translational Pharmacology, Italian National Research Council, Rome, Italy.
Jean BousquetCentre Hospitalier Regional Universitaire de Montpellier, Université de Montpellier, Montpellier, France.
Moises CalderónSection of Allergy and Clinical Immunology, Imperial College of London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.
Enrico CompalatiAllergy and Respiratory Diseases Clinic, Department of Internal Medicine, University of Genoa, Genova, Italy.
Stephen R DurhamAllergy and Clinical Immunology, National Heart and Lung Institute, Imperial College of London, London, UK.
Roy Gerth van WijkDepartment of Allergology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Désirée Larenas-LinnemannAllergy Department, Hospital Medica Sur, Mexico City, Mexico.
Harold NelsonNational Jewish Health, University of Colorado - Denver School of Medicine, Denver, Colorado, USA.
Giovanni PassalacquaAllergy and Respiratory Diseases, IRCCS San Martino IST, University of Genoa, Genova, Italy.
Oliver PfaarCenter for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany.
Nelson RosárioPediatric Allergy and Immunology Division, Hospital de Clínicas, Federal University of Parana, Curitiba, Brazil.
Dermot RyanAcademic Centre of Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Lanny RosenwasserChildren's Mercy Hospital, University of Missouri - Kansas City School of Medicine, Kansas City, Missouri.
Peter Schmid-GrendelmeierAllergy Unit, Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland.
Gianenrico SennaAllergy Unit, Verona General Hospital, Verona, Italy.
Erkka ValovirtaDepartment of Clinical Allergology and Pulmonary Diseases, University of Turku, Finland, and Allergy Clinic, Terveystalo, Turku, Finland.
Hugo Van BeverDepartment of Paediatrics, University Children's Medical Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Pakit VichyanondDepartment of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Ulrich WahnDepartment of Pediatric Pneumology and Immunology, Charité, Humboldt University, Berlin, Germany.
Osman YusufThe Allergy and Asthma Institute, Islamabad, Pakistan.

Funding

Medical Research Council G1000758
6 · The paper itself

Abstract

We have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the originally published paper, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2009", available at http://www.waojournal.org. Namely, these comprise: "Mechanisms of sublingual immunotherapy;" "Clinical efficacy of sublingual immunotherapy" - reporting all the data of all controlled trials published after 2009; "Safety of sublingual immunotherapy" - with the recently published Grading System for adverse reactions; "Impact of sublingual immunotherapy on the natural history of respiratory allergy" - with the relevant evidences published since 2009; "Efficacy of SLIT in children" - with detailed analysis of all the studies; "Definition of SLIT patient selection" - reporting the criteria for eligibility to sublingual immunotherapy; "The future of immunotherapy in the community care setting"; "Methodology of clinical trials according to the current scientific and regulatory standards"; and "Guideline development: from evidence-based medicine to patients' views" - including the evolution of the methods to make clinical recommendations.Additionally, we have added new chapters to cover a few emerging crucial topics: "Practical aspects of schedules and dosages and counseling for adherence" - which is crucial in clinical practice for all treatments; "Perspectives and new approaches" - including recombinant allergens, adjuvants, modified allergens, and the concept of validity of the single products. Furthermore, "Raising public awareness about sublingual immunotherapy", as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail.

Identifiers

PMID24679069
PMCPMC3983904

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.