ArticleBMC research notes2014
Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population.
Article in BMC research notes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Apolipoprotein E (Genes · 2026Article
- Dysbetalipoproteinaemia in genetically predisposed Ghanaians.Lipids in health and disease · 2025Article
- Alzheimer Disease Associated Loci:Biomedicines · 2024Article
- 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Single Nucleotide Variants (SNVs) of Angiotensin-Converting Enzymes (ACE1 and ACE2): A Plausible Explanation for the Global Variation in COVID-19 Prevalence.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2023Review
- Review
- The association ofFrontiers in genetics · 2022Article
- Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.Frontiers in cardiovascular medicine · 2021Review
- What could explain the late emergence of COVID-19 in Africa?New microbes and new infections · 2020Review
- Ethnogeographic prevalence and implications of the 677C>T and 1298A>CBiomarkers in medicine · 2019Article
- Analysis of genetic polymorphism of methylenetetrahydrofolate reductase in a large ethnic Hakka population in southern China.Medicine · 2018Article
- Prevalence of common hereditary risk factors for thrombophilia in Somalia and identification of a novel Gln544Arg mutation in coagulation factor V.Journal of thrombosis and thrombolysis · 2017Article
- Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.PloS one · 2017Article
- Genetic diversity of disease-associated loci in Turkish population.Journal of human genetics · 2015Article
- Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis.Experimental and therapeutic medicine · 2015Article
- Role of apolipoprotein E in neurodegenerative diseases.Neuropsychiatric disease and treatment · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms within the apolipoprotein-E (APOE), Methylenetetrahydrofolate reductase (MTHFR) and Angiotensin I-converting enzyme (ACE) genes has been associated with cardiovascular and cerebrovascular disorders, Alzheimer's disease and other complex diseases in various populations. The aim of the study was to analyze the allelic and genotypic frequencies of APOE, MTHFR C677T and ACE I/D gene polymorphisms in the Zambian population.
resultsThe allele frequencies of APOE polymorphism in the Zambian populations were 13.8%, 59.5% and 26.7% for the ε2, ε3 and ε4 alleles respectively. MTHFR C677T and ACE I/D allele frequencies were 8.6% and 13.8% for the T and D minor alleles respectively. The ε2ε2 genotype and TT genotype were absent in the Zambian population. The genetic distances between Zambian and other African and non-African major populations revealed an independent variability of these polymorphisms.
conclusionWe found that the APOE ε3 allele and the I allele of the ACE were significantly high in our study population while there were low frequencies observed for the MTHFR 677 T and ACE D alleles. Our analysis of the APOE, MTHFR and ACE polymorphisms may provide valuable insight into the understanding of the disease risk in the Zambian population.
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