ReviewDiagnostic pathology2014
Two cases of multiple ossifying fibromas in the jaws.
Review in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Synchronous cemento-ossifying fibromas: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2024Pooled it
- Systematic review of oral manifestations related to hyperparathyroidism.Clinical oral investigations · 2018Pooled it
- Multiple Ossifying Fibroma: A Case Presentation with Comprehensive Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Hyperparathyroidism-Jaw Tumor Syndrome: A Case Diagnosed After the Removal of Multiple Ossifying Fibromas of the Jaws.JCEM case reports · 2025Article
- Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.The Journal of clinical endocrinology and metabolism · 2023Article
- Molecular and Clinical Spectrum of Primary Hyperparathyroidism.Endocrine reviews · 2023Article
- Bilateral ossifying fibroma affecting the jaws: Literature review, rare case report.International journal of surgery case reports · 2023Article
- Ossifying Fibroma in the Maxilla and Mandible: A Case Report With a Brief Literature Review.Cureus · 2023Article
- Alkaline Phosphatase Profile of Patients with Fibro-Osseous Lesions.Iranian journal of otorhinolaryngology · 2022Article
- Combined lesion of central giant cell granuloma and ossifying fibroma: A case report of a rare event in oral cavity.International journal of surgery case reports · 2022Article
- Benign mesenchymal odontogenic tumors of the maxillofacial bones: A report of 3 cases with 3 years follow-up.Journal of oral and maxillofacial pathology : JOMFP · 2022Article
- First presentation of a frameshift mutation in the SETD2 gene of a juvenile psammomatoid ossifying fibroma (JPOF) associated with an aneurysmal bone cyst.Diagnostic pathology · 2021Article
- Parafibromin Abnormalities in Ossifying Fibroma.Journal of the Endocrine Society · 2021Article
- Gnathic Bones and Hyperparathyroidism: A Review on the Metabolic Bony Changes Affecting the Mandible and Maxilla in case of Hyperparathyroidism.Advances in medicine · 2020Review
- Simultaneous presentation of juvenile ossifying fibroma in the maxilla and mandible: a case report.International journal of surgery case reports · 2020Article
- CDC73 gene mutations in sporadic ossifying fibroma of the jaws.Diagnostic pathology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinicopathologic characteristics of multiple ossifying fibroma (OF) are unclear due to the condition's rarity, making diagnosis challenging. Sporadic multiple OFs must be distinguished from hyperparathyroidism-jaw tumour syndrome (HPT-JT) related OF and other fibro-osseous lesions.
methodsMultiple OF cases were identified from ossifying fibroma cases. Clinical data including age, sex, anatomic site, radiographic features, clinical impression, treatment and available follow-up data as well as serum calcium, phosphorus, and parathyroid hormone (PTH) were recorded. GNAS and HRPT2 genetic mutations were examined in the two present cases. Case reports of sporadic multiple ossifying fibroma and HPT-JT-related OF were also reviewed.
resultsThe two present cases were confirmed as sporadic multiple OF, with no genetic GNAS and HRPT2 mutations found. The incidence of sporadic multiple ossifying fibroma was 2.0% (2/102). The total 18 sporadic multiform OF cases were characterized as followed: 13 (72.2%) female; 5 (27.8%) male; mean age 28.6 years; 2/16 (11.1%) cases only in the mandible; 4/18 (22.2%) cases only in the maxilla; and 12/18 (66.7%) cases in both the maxilla and mandible. Radiographically, the lesions were radiolucent in 5/18 (27.8%) cases and mixed density in 13/18 (72.2%) cases. Along with 24 cases of HPT-JT related OF were reviewed, sixteen (66.7%) patients were diagnosed with a single lesion, and 8 patients (33.3%) were diagnosed with multiple jaw lesions.
conclusionsSporadic multiple OFs are very rare, but must be distinguished from HPT-JT related OF. We strongly recommend that patients diagnosed with multiple ossifying fibromas receive serum PTH testing and mutation screening of HRPT2. VIRTUAL SLIDES: http://www.diagnosticpathology.diagnomx.eu/vs/1194507146115753.
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