Evidence map›Paper›PMID 24678735›Full record

ArticleBMC neurology2014

Role of inflammatory markers in Takayasu arteritis disease monitoring.

Timothy E O'Connor, Haley E Carpenter, Sharatchandra Bidari, Michael F Waters, Vishnumurthy Shushrutha Hedna

Registry-linked trialOpen access · goldAbstract readCase Reports
In one paragraph

Article in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03893136 (The Cohort Study of East Chinese Takayasu's Arteritis), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03893136 unknown statusnot on this mapstarted 2016, after this paper: background citation

The Cohort Study of East Chinese Takayasu's Arteritis (ECTA-cohort Study)

TypeobservationalSponsorShanghai Zhongshan HospitalRan2016 to 2026Enrolled1,000ConditionsTakayasu Arteritis, Mechanisms, Defense, Pregnancy Related, Treatment RefusalArmsTocilizumab, Leflunomide
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
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  13. Article
  14. Mechanism and biomarkers in aortitis--a review.Journal of molecular medicine (Berlin, Germany) · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Takayasu's arteritis and liver transplantation: Association and implications.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Timothy E O'Connor
Haley E Carpenter
Sharatchandra Bidari
Michael F Waters
Vishnumurthy Shushrutha HednaDepartment of Neurology, University of Florida, Room L3-100, McKnight Brain Institute 1149 Newell Drive, Gainesville, FL 32611, USA. vhedna@mail.ufl.edu.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTakayasu arteritis (TA) is an idiopathic large-vessel vasculitis that can result in significant morbidity and mortality secondary to progressive stenosis and occlusion. Monitoring disease progression is crucial to preventing relapse, but is often complicated by the lack of clinical symptoms in the setting of active disease. Although acute phase reactants such as ESR and CRP are generally used as an indicator of inflammation and disease activity, mounting evidence suggests that these markers cannot reliably distinguish active from inactive TA. CASE PRESENTATION: We report a 24-year-old Hispanic female with a 5-year history of TA who presented with stroke-like symptoms and evidence of left MCA occlusion on imaging, despite a history of decreasing inflammatory markers. CTA revealed complete occlusion of the left common carotid artery, left subclavian, and left MCA from their origins. It also revealed a striking compensatory circulation supplying the left anterior circulation as well as the left subclavian as a response to progressive stenosis.

conclusionMonitoring ESR and CRP levels alone may not be a reliable method to evaluate disease progression in patients with TA, and should be taken in context with both patient's clinical picture and the imaging. We recommend that serial imaging be performed regularly in the setting of active disease to monitor progression and allow for immediate therapy in response to evidence of disease advancement, with a relaxation of the imaging interval once the disease is presumed inactive.

Indexed as

BiomarkersBlood SedimentationCarotid StenosisCollateral CirculationC-Reactive ProteinFemaleHumansInflammation MediatorsIschemiaMonitoring, PhysiologicStrokeTakayasu ArteritisYoung AdultBiomarkersC-Reactive ProteinInflammation Mediators

Identifiers

PMID24678735
PMCPMC4012521
OpenAlexW1982640920

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.