ArticleMolecular brain2014
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.
Article in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study.Molecular brain · 2018Pooled it
- APC in the nervous system.Medical molecular morphology · 2026Review
- Two independent families with de novo whole APC gene deletion and intellectual disability: a case report.Hereditary cancer in clinical practice · 2025Article
- Rare Germline Variants in the Adenomatous Polyposis Coli Gene Associated with Dental and Osseous Anomalies.International journal of molecular sciences · 2024Review
- Altered microbiota caused by disordered gut motility leads to an overactivation of intestinal immune system in APC1638T mice.Medical molecular morphology · 2023Article
- Effect of simultaneous testing of two mice in the tail suspension test and forced swim test.Scientific reports · 2022Article
- Deficiency ofBrain communications · 2022Article
- A further study on a disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.Medical molecular morphology · 2021Article
- Morphological and functional abnormalities of hippocampus in APCMedical molecular morphology · 2021Article
- Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion.The Journal of cell biology · 2020Article
- Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results.Scientific reports · 2020Article
- Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.The EMBO journal · 2020Article
- Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia.Frontiers in molecular neuroscience · 2019Review
- Validation and application of a novel APC antibody in western blotting, immunoprecipitation, and immunohistochemistry.Medical molecular morphology · 2018Article
- The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.Molecular neurobiology · 2017Article
- A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.Medical molecular morphology · 2017Article
- Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice.Frontiers in behavioral neuroscience · 2017Article
- Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age.Molecular brain · 2016Article
- Differences in neuropsychological and behavioral parameters and brain structure in patients with familial adenomatous polyposis: a sibling-paired study.Hereditary cancer in clinical practice · 2016Article
- Cohort Removal Induces Changes in Body Temperature, Pain Sensitivity, and Anxiety-Like Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLoss of adenomatous polyposis coli (APC) gene function results in constitutive activation of the canonical Wnt pathway and represents the main initiating and rate-limiting event in colorectal tumorigenesis. APC is likely to participate in a wide spectrum of biological functions via its different functional domains and is abundantly expressed in the brain as well as in peripheral tissues. However, the neuronal function of APC is poorly understood. To investigate the functional role of Apc in the central nervous system, we analyzed the neurological phenotypes of Apc1638T/1638T mice, which carry a targeted deletion of the 3' terminal third of Apc that does not affect Wnt signaling.
resultsA series of behavioral tests revealed a working memory deficit, increased locomotor activity, reduced anxiety-related behavior, and mildly decreased social interaction in Apc1638T/1638T mice. Apc1638T/1638T mice showed abnormal morphology of the dendritic spines and impaired long-term potentiation of synaptic transmission in the hippocampal CA1 region. Moreover, Apc1638T/1638T mice showed abnormal dopamine and serotonin distribution in the brain. Some of these behavioral and neuronal phenotypes are related to symptoms and endophenotypes of schizophrenia.
conclusionsOur results demonstrate that the C-terminus of the Apc tumor suppressor plays a critical role in cognitive and neuropsychiatric functioning. This finding suggests a potential functional link between the C-terminus of APC and pathologies of the central nervous system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.