ReviewArthritis2014
Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism.
Review in Arthritis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Glucosamine supplementation in the treatment of temporomandibular joint disorders: a systematic review and meta-analysis.Frontiers in dental medicine · 2026Pooled it
- Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Glucose transporter 2‑transported glucosamine inhibits glycolysis in cancer cell lines through competition with glucose for hexokinase II.Oncology reports · 2025Article
- Effects of Glucosamine in the Temporomandibular Joint Osteoarthritis: A Review.Current rheumatology reviews · 2024Review
- Subchondral bone in knee osteoarthritis: bystander or treatment target?Skeletal radiology · 2023Review
- The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model.International journal of molecular sciences · 2021Article
- Oral intake ofHeliyon · 2020Article
- Expert Opinion on the Extensive Use of Prescription Crystalline Glucosamine Sulfate in the Multimodal Treatment of Osteoarthritis in Ukraine, Kazakhstan, Uzbekistan, and Armenia.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2020Article
- Nutraceuticals: Reviewing their Role in Chronic Disease Prevention and Management.Pharmaceutical medicine · 2019Review
- Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.International journal of molecular medicine · 2018Article
- Protective effects of glucosamine and its acetylated derivative on serum/glucose deprivation-induced PC12 cells death: Role of reactive oxygen species.Research in pharmaceutical sciences · 2018Article
- Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight.Cell & bioscience · 2017Review
- Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors.Scientific reports · 2016Article
- Article
- Comparison of various SYSADOA for the osteoarthritis treatment: an experimental study in rabbits.BMC musculoskeletal disorders · 2015Article
- The role of aggrecan in normal and osteoarthritic cartilage.Journal of experimental orthopaedics · 2014Article
- Evidence-informed recommendations for rehabilitation with older adults living with HIV: a knowledge synthesis.BMJ open · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis is a chronic degenerative disorder that currently represents one of the main causes of disability within the elderly population and an important presenting complaint overall. The pathophysiologic basis of osteoarthritis entails a complex group of interactions among biochemical and mechanical factors that have been better characterized in light of a recent spike in research on the subject. This has led to an ongoing search for ideal therapeutic management schemes for these patients, where glucosamine is one of the most frequently used alternatives worldwide due to their chondroprotective properties and their long-term effects. Its use in the treatment of osteoarthritis is well established; yet despite being considered effective by many research groups, controversy surrounds their true effectiveness. This situation stems from several methodological aspects which hinder appropriate data analysis and comparison in this context, particularly regarding objectives and target variables. Similar difficulties surround the assessment of the potential ability of glucosamine formulations to alter glucose metabolism. Nevertheless, evidence supporting diabetogenesis by glucosamine remains scarce in humans, and to date, this association should be considered only a theoretical possibility.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.