ArticleEuropean journal of microbiology & immunology2014
Spinal cord pathology in chronic experimental Toxoplasma gondii infection.
Article in European journal of microbiology & immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Host-parasite interaction in latent cerebral toxoplasmosis: The role of cytokine response in a mouse model.Open veterinary journal · 2025Article
- Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.Journal of neuroinflammation · 2022Article
- Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders.Metabolic brain disease · 2022Review
- Persisting Microbiota and Neuronal Imbalance FollowingFrontiers in immunology · 2022Article
- The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis.Frontiers in immunology · 2021Article
- Kinematic Locomotion Changes in C57BL/6 Mice Infected withMicroorganisms · 2019Article
- Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.Journal of neuroinflammation · 2019Article
- Advances and Challenges in Understanding Cerebral Toxoplasmosis.Frontiers in immunology · 2019Review
- p75Glia · 2019Article
- Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition.Journal of neuroinflammation · 2018Article
- Peroral Low-DoseEuropean journal of microbiology & immunology · 2018Article
- Behavior of Neutrophil Granulocytes duringFrontiers in cellular and infection microbiology · 2017Article
- Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.Acta neuropathologica communications · 2016Article
- Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.Inflammation · 2016Article
- Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria.PloS one · 2015Article
- Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.PLoS biology · 2015Article
- The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.Gut pathogens · 2014Article
- Article
- Longitudinally Extensive Transverse Myelitis Due to Toxoplasma: An Autopsy Study.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with the protozoan Toxoplasma (T.) gondii causes chronic infection of the central nervous system and can lead to life-threatening encephalomyelitis in immunocompromised patients. While infection with T. gondii has long time been considered asymptomatic in immunocompetent hosts, this view is challenged by recent reports describing links between seropositivity and behavioral alterations. However, past and current researches are mainly focused on the brain during Toxoplasma encephalitis, neglecting the spinal cord as a key structure conveying brain signals into motion. Therefore, our study aimed to fill the gap and describes the spinal cord pathology in an experimental murine model of toxoplasmosis. In the spinal cord, we found distinct histopathological changes, inflammatory foci and T. gondii cysts similar to the brain. Furthermore, the recruitment of immune cells from the periphery was detected. Moreover, resident microglia as well as recruited monocytes displayed an increased MHC classes I and II expression. Additionally, the expression of pro- and anti-inflammatory cytokines was enhanced in the brain as well as in the spinal cord. In summary, the pathology observed in the spinal cord was similar to the previously described changes in the brain during the infection. This study provides the first detailed description of histopathological and immunological alterations due to experimental T. gondii induced myelitis in mice. Thus, our comparison raises awareness of the importance of the spinal cord in chronic T. gondii infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.