Evidence map›Paper›PMID 24678280›Full record

Trial reportTheScientificWorldJournal2014

Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.

Shiva Ganjali, Amirhossein Sahebkar, Elahe Mahdipour, Khadijeh Jamialahmadi, Sepideh Torabi, Saeed Akhlaghi, Gordon Ferns, Seyed Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 5 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03917784 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes

TypeinterventionalSponsorHospital General de México Dr. Eduardo LiceagaRan2019 to 2020Enrolled142ConditionsPreDiabetesArmsCurcumin, Starch
NCT07436130 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Immunomodulatory Effect of Curcumin in Critically Ill Patients With Sepsis at the Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde": A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2026 to 2027Enrolled56ConditionsSepsisArmsCurcumin, Placebo
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shiva GanjaliCardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Department of Biotechnology, Science & Research Branch, Islamic Azad University, Tehran, Iran.ORCID 0000-0002-7446-3927
Amirhossein SahebkarBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Neurogenic Inflammation Research Centre, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-8656-1444
Elahe MahdipourDepartment of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Khadijeh JamialahmadiBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sepideh TorabiDepartment of Plant Breeding, Science & Research Branch, Islamic Azad University, Tehran, Iran.
Saeed AkhlaghiDeputy of Research, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon FernsDivision of Medical Education, Mayfield House, University of Brighton, Room 342, Brighton BN1 9PH, UK.ORCID 0000-0002-0957-8349
Seyed Mohammad Reza ParizadehBiochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid Ghayour-MobarhanBiochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IRUniversity of Brighton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy of curcumin, a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects, on the serum levels of a panel of cytokines and mediators in obese individuals.

methodsThirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks. Following a 2-week wash-out period, each group was assigned to the alternate treatment regimen for another 4 weeks. Serum samples were collected at the start and end of each study period. Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method.

resultsMean serum IL-1β (P = 0.042), IL-4 (P = 0.008), and VEGF (P = 0.01) were found to be significantly reduced by curcumin therapy. In contrast, no significant difference was observed in the concentrations of IL-2, IL-6, IL-8, IL-10, IFNγ, EGF, and MCP-1.

conclusionsThe findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.

Indexed as

AdolescentAdultAgedAnti-Inflammatory Agents, Non-SteroidalCross-Over StudiesCurcuminCytokinesDrug CombinationsHumansImmunologic FactorsMiddle AgedObesityTreatment OutcomeYoung AdultAnti-Inflammatory Agents, Non-SteroidalCurcuminCytokinesDrug CombinationsImmunologic Factors

Identifiers

PMID24678280
PMCPMC3942342
OpenAlexW1969731650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.