ArticleInterdisciplinary toxicology2013
Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiation.
Article in Interdisciplinary toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter.Journal of cosmetic dermatology · 2025Trial
- Comparative analysis of wavelength-specific UV stress granule formation.bioRxiv : the preprint server for biology · 2026Article
- Article
- Topical Application of M89PF Containing Vichy Mineralising Water and Probiotic Fractions Prevents Cutaneous Damage Induced by Exposure to UV and OClinical, cosmetic and investigational dermatology · 2023Article
- Ultraviolet Light Protection: Is It Really Enough?Antioxidants (Basel, Switzerland) · 2022Review
- The Metabolite Profile in Culture Supernatant ofPlants (Basel, Switzerland) · 2021Article
- CYP11A1-derived vitamin DFree radical biology & medicine · 2020Article
- Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.Experimental and therapeutic medicine · 2020Article
- Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- IL-6 Negatively Regulates IL-22RJournal of immunology research · 2019Article
- Elicited ROS Scavenging Activity, Photoprotective, and Wound-Healing Properties of Collagen-Derived Peptides from the Marine SpongeMarine drugs · 2018Article
- Connexin Communication Compartments and Wound Repair in Epithelial Tissue.International journal of molecular sciences · 2018Review
- Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis.Clinical proteomics · 2018Article
- Evaluation of oral keratinocyte progenitor and T-lymphocite cells response during early healing after augmentation of keratinized gingiva with a 3D collagen matrix - a pilot study.BMC oral health · 2016Article
- Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development.International journal of molecular sciences · 2016Article
- Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling.The Journal of investigative dermatology · 2016Article
- Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin.Oxidative medicine and cellular longevity · 2016Article
- Low-level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair.Journal of biophotonics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin exposure to ultraviolet (UV) light evokes a complex stress response in keratinocytes. Keratin filament organization provides structural stability and mechanical integrity of keratinocytes. Involucrin is a transglutaminase substrate protein contributing to the formation of insoluble cornified envelopes. However, a more complex role for keratins and involucrin has been proposed, including the regulation of cell stress response. The aim was to evaluate modulations of keratin 1, 10 and involucrin expression in HaCaT in the light of the complex response of these cells to UV-B radiation, including effects on c-Jun and matrix metalloproteinase 1 (MMP-1) gene expression and production of interleukin (IL) 6 and 8. A UV-B (300±5 nm) dose of 10 mJ/cm(2) was selected since this dose resulted in a partial decrease in cell viability in contrast to higher UV-B doses, which induced complete cell death 48 h after treatment. The UV-B radiation induced significant expression of keratin 1 and 10 and decreased expression of involucrin. This was accompanied by increased expression of c-Jun and MMP-1 and IL-6 and IL-8 production. The data suggest that the expression of keratin 1, 10 and involucrin is modulated in HaCaT keratinocytes as a part of the complex stress response to UV radiation.
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Registered trials
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