ReviewMacromolecular bioscience2014
Bioreducible polycations in nucleic acid delivery: past, present, and future trends.
Review in Macromolecular bioscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 99 citations in OpenAlex.
- Grafting Cell-Penetrating Poly(disulfide)s to Substrates of Interest: Dynamic Covalent Bioconjugation for Traceless Delivery.Angewandte Chemie (International ed. in English) · 2026Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Peptide dendrimers transfecting CRISPR/Cas9 plasmid DNA: optimization and mechanism.RSC chemical biology · 2024Article
- Reversible Stabilization of Nanofiber-Polyplexes through Introducing Cross-Linkages.Journal of functional biomaterials · 2023Article
- Thiol-Disulfide Exchange as a Route for Endosomal Escape of Polymeric Nanoparticles.Angewandte Chemie (International ed. in English) · 2022Article
- Article
- Cyclic Thiosulfonates for Thiol-Mediated Uptake: Cascade Exchangers, Transporters, Inhibitors.JACS Au · 2022Article
- Oligonucleotide Phosphorothioates Enter Cells by Thiol-Mediated Uptake.Angewandte Chemie (International ed. in English) · 2021Article
- Thiol-Mediated Uptake.JACS Au · 2021Review
- Inorganic Nanomaterial-Mediated Gene Therapy in Combination with Other Antitumor Treatment Modalities.Advanced functional materials · 2021Article
- Inhibitors of thiol-mediated uptake.Chemical science · 2020Article
- Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids.Molecular pharmaceutics · 2020Article
- In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture.Molecules (Basel, Switzerland) · 2020Article
- Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks.Journal of the American Chemical Society · 2020Article
- Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides.Beilstein journal of organic chemistry · 2020Article
- Cell-Penetrating Dynamic-Covalent Benzopolysulfane Networks.Angewandte Chemie (International ed. in English) · 2019Article
- Recent advances in the development of gene delivery systems.Biomaterials research · 2019Review
- Design of PEI-conjugated bio-reducible polymer for efficient gene delivery.International journal of pharmaceutics · 2018Article
- Article
- Conjugate Polyplexes with Anti-Invasive Properties and Improved siRNA Delivery In Vivo.Bioconjugate chemistry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.