ArticleDevelopmental neurobiology2015
REM sleep twitches rouse nascent cerebellar circuits: Implications for sensorimotor development.
Article in Developmental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- A transient feature of the inferior olive supports the development of cerebellar internal models.bioRxiv : the preprint server for biology · 2025Article
- Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation.Neurobiology of sleep and circadian rhythms · 2025Article
- Novel Electrophysiological Signatures of Learning and Forgetting in Human Rapid Eye Movement Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
- Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.Dystonia (Lausanne, Switzerland) · 2022Article
- Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus.Current biology : CB · 2021Article
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
- The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers.Frontiers in integrative neuroscience · 2021Article
- Article
- Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Article
- Phantom Limbs, Neuroprosthetics, and the Developmental Origins of Embodiment.Trends in neurosciences · 2017Review
- Wakefulness suppresses retinal wave-related neural activity in visual cortex.Journal of neurophysiology · 2017Article
- Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network.Current biology : CB · 2017Article
- A new view of "dream enactment" in REM sleep behavior disorder.Sleep medicine reviews · 2016Review
- Spontaneous activity and functional connectivity in the developing cerebellorubral system.Journal of neurophysiology · 2016Article
- Gating of reafference in the external cuneate nucleus during self-generated movements in wake but not sleep.eLife · 2016Article
- Neuroscience: A Distributed Neural Network Controls REM Sleep.Current biology : CB · 2016Article
- Twitch-related and rhythmic activation of the developing cerebellar cortex.Journal of neurophysiology · 2015Article
- Sensorimotor processing in the newborn rat red nucleus during active sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cerebellum is critical for sensorimotor integration and undergoes extensive postnatal development. During the first postnatal week in rats, climbing fibers polyinnervate Purkinje cells and, before granule cell migration, mossy fibers make transient, direct connections with Purkinje cells. Activity-dependent processes are assumed to play a critical role in the development and refinement of these and other aspects of cerebellar circuitry. However, the sources and patterning of activity have not been described. We hypothesize that sensory feedback (i.e., reafference) from myoclonic twitches in sleeping newborn rats is a prominent driver of activity for the developing cerebellum. Here, in 6-day-old rats, we show that Purkinje cells exhibit substantial state-dependent changes in complex and simple spike activity-primarily during active sleep. In addition, this activity increases significantly during bouts of twitching. Moreover, the surprising observation of twitch-dependent increases in simple spike activity at this age suggests a functional engagement of mossy fibers before the parallel fiber system has developed. Based on these and other results, we propose that twitching comprises a unique class of self-produced movement that drives critical aspects of activity-dependent development in the cerebellum and other sensorimotor systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.