ArticleClinical and experimental immunology1989
Antigenic relationships between the surface-exposed, secreted and somatic materials of the nematode parasites Ascaris lumbricoides, Ascaris suum, and Toxocara canis.
Article in Clinical and experimental immunology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- The immunomodulatory p43 secreted protein of Trichuris whipworm parasites is a lipid carrier that binds signalling lipids and precursors.Scientific reports · 2025Article
- Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025Review
- Dot enzyme-linked immunosorbent assay (ELISA) for the detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Identification and characterization of the major pseudocoelomic proteins of the giant kidney worm, Dioctophyme renale.Parasites & vectors · 2017Article
- Seroprevalence of five parasitic pathogens in pregnant women in ten Caribbean countries.Parasitology research · 2017Article
- Optimal ELISA antigen for the diagnosis of Ascaris suum infection in humans.Parasitology research · 2016Article
- Distribution of Helminth Parasites in Intestines and Their Seasonal Rate of Infestation in Three Freshwater Fishes of Kashmir.Journal of parasitology research · 2016Article
- Immunoblot for the detection of Ascaris suum-specific antibodies in patients with visceral larva migrans (VLM) syndrome.Parasitology research · 2015Article
- In vitro culture of Parascaris equorum larvae and initial investigation of parasite excretory-secretory products.Parasitology research · 2014Article
- Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases.PLoS neglected tropical diseases · 2013Article
- Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity.Clinical microbiology reviews · 2008Review
- The polyprotein and FAR lipid binding proteins of nematodes: shape and monomer/dimer states in ligand-free and bound forms.European biophysics journal : EBJ · 2003Article
- The ABA-1 allergen of the nematode Ascaris suum: epitope stability, mass spectrometry, and N-terminal sequence comparison with its homologue in Toxocara canis.Clinical and experimental immunology · 1993Article
- MHC class II (I-A) region control of the IgE antibody repertoire to the ABA-1 allergen of the nematode Ascaris.Immunology · 1991Article
- The specificity of the antibody response to internal antigens of Ascaris: heterogeneity in infected humans, and MHC (H-2) control of the repertoire in mice.Clinical and experimental immunology · 1990Article
- N-terminal amino acid sequence identity between a major allergen of Ascaris lumbricoides and Ascaris suum, and MHC-restricted IgE responses to it.Immunology · 1990Article
- Immunoregulatory Effects of Somatic Extract ofIranian journal of parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The cosmopolitan nematode parasites Ascaris lumbricoides, Ascaris suum, and Toxocara canis are closely related phylogenetically, and are all pathogenic to man. In the case of the latter, the antigens released by the tissue-invasive parasitic larvae in vitro ('excretory/secretory' or 'ES' antigens) are routinely used for serodiagnostic purposes. Here we have found, using radioimmunoprecipitation with defined rabbit antiserum, and SDS-PAGE, that there is a significant antigenic similarity between the secreted and somatic antigens of the three nematodes, and have characterized cross-reactive components. Among these is a 14 kD internal protein which has a homologue in all three parasites. This molecule is the subject of an IgG antibody response in Ascaris infection, but there is no measurable response to it in toxocariasis. Lastly, using quantitative immunofluorescence, the antigens exposed on the surface of intact, living, larvae were found to be cross-reactive or specific depending on the developmental stage of the parasites. This means that the surface of tissue-invasive Ascaris larvae bears stage-specific epitopes.
Indexed as
Identifiers
2467777PMC1541960W2416837773What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.