ArticleProteins2014
WeFold: a coopetition for protein structure prediction.
Article in Proteins, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Assessment of Two Restraint Potentials for Coarse-Grained Chemical-Cross-Link-Assisted Modeling of Protein Structures.Journal of chemical information and modeling · 2024Article
- Role of environmental specificity in CASP results.BMC bioinformatics · 2023Article
- Engagement of intrinsic disordered proteins in protein-protein interaction.Frontiers in molecular biosciences · 2023Article
- The Possible Mechanism of Amyloid Transformation Based on the Geometrical Parameters of Early-Stage Intermediate in Silico Model for Protein Folding.International journal of molecular sciences · 2022Article
- Computational Models for the Study of Protein Aggregation.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Assessment of protein model structure accuracy estimation in CASP13: Challenges in the era of deep learning.Proteins · 2019Article
- Structural analysis of the Aβ(11-42) amyloid fibril based on hydrophobicity distribution.Journal of computer-aided molecular design · 2019Article
- Scientific Discovery Games for Biomedical Research.Annual review of biomedical data science · 2019Article
- An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12.Scientific reports · 2018Article
- Performance of protein-structure predictions with the physics-based UNRES force field in CASP11.Bioinformatics (Oxford, England) · 2016Article
- Structural Interface Forms and Their Involvement in Stabilization of Multidomain Proteins or Protein Complexes.International journal of molecular sciences · 2016Article
- Does Cation Size Affect Occupancy and Electrostatic Screening of the Nucleic Acid Ion Atmosphere?Journal of the American Chemical Society · 2016Article
- Citizen Science Initiatives: Engaging the Public and Demystifying Science.Journal of microbiology & biology education · 2016Article
- Crowdsourcing in biomedicine: challenges and opportunities.Briefings in bioinformatics · 2016Review
- Exploring Polypharmacology in Drug Discovery and Repurposing Using the CANDO Platform.Current pharmaceutical design · 2016Review
- Achievements and challenges in structural bioinformatics and computational biophysics.Bioinformatics (Oxford, England) · 2015Article
Corrections and comments
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Authors and funding
30 authors.
Funding
Abstract
The protein structure prediction problem continues to elude scientists. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction targets. To address this challenge, a social-media based worldwide collaborative effort, named WeFold, was undertaken by 13 labs. During the collaboration, the laboratories were simultaneously competing with each other. Here, we present the first attempt at "coopetition" in scientific research applied to the protein structure prediction and refinement problems. The coopetition was possible by allowing the participating labs to contribute different components of their protein structure prediction pipelines and create new hybrid pipelines that they tested during CASP10. This manuscript describes both successes and areas needing improvement as identified throughout the first WeFold experiment and discusses the efforts that are underway to advance this initiative. A footprint of all contributions and structures are publicly accessible at http://www.wefold.org.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.