Evidence map›Paper›PMID 24677095›Full record

ArticleJournal of natural medicines2018

Pharmacological evaluation of the efficacy of Dysoxylum binectariferum stem bark and its active constituent rohitukine in regulation of dyslipidemia in rats.

Sunil K Mishra, Shashi Tiwari, Shishir Shrivastava, Ravi Sonkar, Vaibhav Mishra, Sunil K Nigam, Anil K Saxena, Gitika Bhatia, Snober S Mir

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. A wound inducible chalcone synthase gene fromPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sunil K MishraMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
Shashi TiwariDepartment of Pesticide Toxicology, CSIR-Indian Institute of Toxicology Research, Lucknow, 226001, India.
Shishir ShrivastavaMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
Ravi SonkarDepartment of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
Vaibhav MishraDepartment of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
Sunil K NigamDepartment of Chemistry, Govt. Science College Rewa, Rewa, 486001, India.
Anil K SaxenaMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
Gitika BhatiaDepartment of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
Snober S MirDepartment of Biotechnology, Integral University, Lucknow, 226026, India. mir_51@yahoo.in.
Central Drug Research Institute · INIndian Institute of Toxicology Research · INIntegral University · INShyam Shah Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antidyslipidemic effect of the ethanolic extract of Dysoxylum binectariferum stem bark and its major active constituent rohitukine was evaluated in a high fat diet (HFD)-fed dyslipidemic rat model. Chronic feeding of ethanolic extract (200 mg/kg) in HFD-fed rats showed significant lipid lowering activity. The bioassay guided fractionation of ethanolic extract resulted in the identification of known alkaloid rohitukine as major active constituent. Rohitukine (50 mg/kg) significantly decreased the plasma levels of total cholesterol (24 %), phospholipids (25 %), triglycerides (27 %), very low density lipoprotein (27 %) and low density lipoprotein (32 %) accompanied with an increase in high density lipoprotein (21 %). The present study demonstrated that ethanolic extract of Dysoxylum binectariferum stem bark and its major constituent rohitukine both have antidyslipidemic as well as antioxidant potentials. The antidyslipidemic activity of rohitukine can be correlated to its effect on enzymes involved in lipid metabolism.

Indexed as

AnimalsAntioxidantsChromonesDyslipidemiasLipid MetabolismMalePiperidinesRats5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-oneAntioxidantsChromonesPiperidinesAntidyslipidemicAntioxidantDyslipidemiaDysoxylum binectariferumHMG–CoA reductaseLecithin-cholesterol acyl transferase activity

Identifiers

PMID24677095
OpenAlexW2028175827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.