ArticleMolecular medicine reports2014
Preconditioned hyperbaric oxygenation protects skin flap grafts in rats against ischemia/reperfusion injury.
Article in Molecular medicine reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Hyperbaric Oxygen Therapy for Soft Tissue Injury in Open Musculoskeletal Trauma: A Prospective Study.Cureus · 2023Article
- Current Status of Experimental Animal Skin Flap Models: Ischemic Preconditioning and Molecular Factors.International journal of molecular sciences · 2022Review
- Overexpression of eRF3a Promotes Cell Proliferation and Migration in Liver Cancer.Current medical science · 2022Article
- Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair.International journal of molecular sciences · 2021Review
- Effects of Apigenin Treatment on Random Skin Flap Survival in Rats.Frontiers in pharmacology · 2021Article
- Hyperbaric Oxygen Preconditioning Can Reduce Postabdominoplasty Complications: A Retrospective Cohort Study.Plastic and reconstructive surgery. Global open · 2019Article
- [Propofol combined with hypoxia induces cognitive dysfunction in immature ratsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- An overview of protective strategies against ischemia/reperfusion injury: The role of hyperbaric oxygen preconditioning.Brain and behavior · 2018Review
- Ischaemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms.Diving and hyperbaric medicine · 2017Review
- Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation.Neural regeneration research · 2017Review
- Bilirubin provides perforator flap protection from ischaemia-reperfusion injury in a rat model: a preliminary result.International wound journal · 2016Article
- Preoperative Stress Conditioning in Humans: Is Oxygen the Drug of Choice?Advances in experimental medicine and biology · 2016Article
- Improvement of tissue survival of skin flaps by 5α-reductase inhibitors: possible involvement of nitric oxide and inducible nitric oxide synthase.Iranian biomedical journal · 2015Article
- Hyperbaric oxygen therapy in China.Medical gas research · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperbaric oxygen (HBO) therapy is an effective therapy for ischemia/reperfusion (I/R) injury of the brain, small intestine, testes and liver. However, the detailed molecular mechanisms underlying the effect of HBO therapy remain undetermined. In the current study, the hypothesis that preconditioning rats with HBO protects grafted skin flaps against subsequent I/R injury was investigated. In addition, the molecular mechanisms underlying HBO therapy were characterized by analyzing the roles of the following important inflammatory factors: High mobility group protein 1 (HMGB1) and nuclear factor-κ B (NF-κB). A total of 40 rats were randomly divided into the following five groups: (i) Sham surgery (SH); (ii) ischemia followed by reperfusion 3 days following surgery (I/R3d); (iii) ischemia followed by reperfusion 5 days following surgery (I/R5d); (iv) HBO preconditioning (HBO-PC) and ischemia followed by reperfusion 3 days following surgery (HBO-PC+3d); and (v) HBO-PC and ischemia followed by reperfusion 5 days following surgery (HBO-PC+5d). For the surgical procedure, all pedicled skin flaps were first measured and elevated (9x6 cm). The feeding vessels of the skin flaps were subsequently clamped for 3 h and released to restore blood flow. The rats in the HBO-PC+3d and HBO-PC+5d groups received 1 h HBO for 3 and 5 consecutive days, respectively, prior to surgery. Following surgery, the rats were euthanized, and grafted tissues were collected for western blotting and immunohistochemistry. HBO-PC increased blood perfusion in epigastric skin flaps and attenuated I/R injury following skin flap graft. Additionally, the elevated expression of HMGB1 and NF-κB proteins during I/R injury was attenuated by HBO-PC treatment. HBO-PC may therefore be applied to reduce I/R injury and improve the survival rate of grafted skin flaps. The molecular mechanisms underlying the effect of HBO therapy are associated with the attenuation of inflammatory responses.
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