Evidence map›Paper›PMID 24676848›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2014

Effects of 18-month low-magnitude high-frequency vibration on fall rate and fracture risks in 710 community elderly--a cluster-randomized controlled trial.

K S Leung, C Y Li, Y K Tse, T K Choy, P C Leung, V W Y Hung, S Y Chan, A H C Leung, W H Cheung

5 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 57 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03380884 nacompletednot on this mapstarted 2017, after this paper: background citation

Vibration Therapy as a Rehabilitation Intervention for Postural Training and Fall Prevention After Distal Radius Fracture in Elderly Patients: A Randomized Controlled Trial

TypeinterventionalSponsorPrince of Wales Hospital, Shatin, Hong KongRan2017 to 2023Enrolled232ConditionsDistal Radius Fracture, Fall PatientsArmsLow-magnitude high-frequency vibration (LMHFV)
NCT04028206 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Elastic-band Resistance Exercise or Vibration Treatment With Hydroxymethylbutyrate (HMB) Supplement for Sarcopenic Older People

TypeinterventionalSponsorChinese University of Hong KongRan2019 to 2023Enrolled144ConditionsSarcopeniaArmsHydroxymethylbutyrate, Low-magnitude High Frequency Vibration (LMHFV), Elastic-band Exercise
NCT04063891 nacompletednot on this mapstarted 2021, after this paper: background citation

Vibration Therapy as an Intervention for Enhancing Trochanteric Hip Fracture Healing in Elderly Patients: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorPrince of Wales Hospital, Shatin, Hong KongRan2021 to 2025Enrolled83ConditionsHip FracturesArmsLow-magnitude high-frequency vibration (LMHFV)
NCT04180267 naterminatednot on this mapstarted 2019, after this paper: background citation

Efficacy of Low-magnitude High-frequency Vibration (LMHFV) on Musculoskeletal Health of Subjects on Wheelchair, a Randomized Controlled Study.

TypeinterventionalSponsorChinese University of Hong KongRan2019 to 2024Enrolled37ConditionsVibration Therapy, Wheelchair, OsteoporosisArmsLow-magnitude High-frequency Vibration
NCT05525039 narecruitingnot on this mapstarted 2023, after this paper: background citation

Dissecting the Therapeutic Mechanism of an Effective Combination Treatment Targeting Neuromuscular Junction Dengeneration and Myosteatosis to Combat Sarcopenia

TypeinterventionalSponsorChinese University of Hong KongRan2023 to 2025Enrolled200ConditionsSarcopenia, Connective Tissue Diseases in Old Age, Musculoskeletal AbnormalitiesArmsLow-magnitude High-frequency Vibration, β-hydroxy β-methylbutyrate (HMB) supplement, Protein supplement
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Guideline
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  7. Exercise for preventing falls in older people living in the community.The Cochrane database of systematic reviews · 2019
    Pooled it
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  10. Effects of whole body vibration on bone mineral density in postmenopausal women: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Pooled it
  11. Pooled it
  12. Trial
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  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

K S LeungDepartment of Orthopaedics and Traumatology, 5/F, Clinical Sciences Building, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
C Y Li
Y K Tse
T K Choy
P C Leung
V W Y Hung
S Y Chan
A H C Leung
W H Cheung

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThis study is a prospective cluster-randomized controlled clinical trial involving 710 elderly subjects to investigate the long-term effects of low-magnitude high-frequency vibration (LMHFV) on fall and fracture rates, muscle performance, and bone quality. The results confirmed that LMHFV is effective in reducing fall incidence and enhancing muscle performance in the elderly.

introductionFalls are direct causes of fragility fracture in the elderly. LMHFV has been shown to improve muscle function and bone quality. This study is to investigate the efficacy of LMHFV in preventing fall and fractures among the elderly in the community.

methodsA cluster-randomized controlled trial was conducted with 710 postmenopausal females over 60 years. A total of 364 participants received daily 20 min LMHFV (35 Hz, 0.3 g), 5 days/week for 18 months; 346 participants served as control. Fall or fracture rate was taken as the primary outcome. Also, quadriceps muscle strength, balancing abilities, bone mineral density (BMD), and quality of life (QoL) assessments were done at 0, 9, and 18 months.

resultsWith an average of 66.0% compliance in the vibration group, 18.6% of 334 vibration group subjects reported fall or fracture incidences compared with 28.7% of 327 in the control (adjusted HR = 0.56, p = 0.001). The fracture rate of vibration and control groups were 1.1 and 2.3 % respectively (p = 0.171). Significant improvements were found in reaction time, movement velocity, and maximum excursion of balancing ability assessment, and also the quadriceps muscle strength (p < 0.001). No significant differences were found in the overall change of BMD. Minimal adverse effects were documented.

conclusionLMHFV is effective in fall prevention with improved muscle strength and balancing ability in the elderly. We recommend its use in the community as an effective fall prevention program and to decrease related injuries.

Indexed as

Accidental FallsAgedBone DensityFemaleHumansMiddle AgedMuscle StrengthOsteoporosis, PostmenopausalOsteoporotic FracturesPostural BalanceProspective StudiesQuadriceps MuscleQuality of LifeRisk FactorsSingle-Blind MethodTreatment Outcome

Identifiers

PMID24676848

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.