ArticleMemorias do Instituto Oswaldo Cruz2014
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections.
Article in Memorias do Instituto Oswaldo Cruz, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- A systematic review and meta-analysis of blood level of MCP-1/CCL-2 in severe and uncomplicated malaria.Scientific reports · 2024Pooled it
- Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis.Malaria journal · 2022Pooled it
- Reduction in total leukocytes in malaria patients compared to febrile controls: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria: a systematic review and meta-analysis.Infectious diseases of poverty · 2018Pooled it
- Assessment of Cytokines TNF-alpha, IFN-gamma, TGF-beta-1, and IL-10 in Malaria Patients of the River Nile State , Sudan: A critical study of immune response.BMC immunology · 2025Article
- Screening Clinical, Laboratory and Host Markers for Diagnosis of Disease Severity inIndian journal of microbiology · 2024Article
- Immunofluorescence study of cytoskeleton in endothelial cells induced with malaria sera.Malaria journal · 2024Article
- Cytokine gene polymorphisms implicated in the pathogenesis ofFrontiers in immunology · 2024Review
- Haematological parameters and their correlation with the degree of malaria parasitaemia among outpatients attending a polyclinic.Malaria journal · 2023Article
- Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines.Journal of immunology research · 2021Review
- Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes.PLoS neglected tropical diseases · 2020Article
- Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities.Malaria journal · 2019Article
- Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.Science immunology · 2019Article
- Plasma cytokine profiles associated withAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Article
- Analysis of the lymphocyte cell population during malaria caused by Plasmodium vivax and its correlation with parasitaemia and thrombocytopaenia.Malaria journal · 2018Article
- Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon.Immunity, inflammation and disease · 2018Article
- Potential Role for Regulatory B Cells as a Major Source of Interleukin-10 in Spleen from Plasmodium chabaudi-Infected Mice.Infection and immunity · 2018Article
- Article
- To B or Not to B: Understanding B Cell Responses in the Development of Malaria Infection.Frontiers in immunology · 2018Review
- Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria.International journal of medical microbiology : IJMM · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated various cytokines in a single patient group during the acute and convalescent phases of infection. The aim of this study was to sequentially characterise alterations in haematological patters and circulating plasma cytokine and chemokine levels in patients infected with Plasmodium vivax or Plasmodium falciparum from a Brazilian endemic area during the acute and convalescent phases of infection. During the acute phase, thrombocytopaenia, eosinopaenia, lymphopaenia and an increased number of band cells were observed in the majority of the patients. During the convalescent phase, the haematologic parameters returned to normal. During the acute phase, P. vivax and P. falciparum patients had significantly higher interleukin (IL)-6, IL-8, IL-17, interferon-γ, tumour necrosis factor (TNF)-α, macrophage inflammatory protein-1β and granulocyte-colony stimulating factor levels than controls and maintained high levels during the convalescent phase. IL-10 was detected at high concentrations during the acute phase, but returned to normal levels during the convalescent phase. Plasma IL-10 concentration was positively correlated with parasitaemia in P. vivax and P. falciparum-infected patients. The same was true for the TNF-α concentration in P. falciparum-infected patients. Finally, the haematological and cytokine profiles were similar between uncomplicated P. falciparum and P. vivax infections.
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