ArticleJournal of applied oral science : revista FOB2014
Serum levels of inflammatory markers in type 2 diabetes patients with chronic periodontitis.
Article in Journal of applied oral science : revista FOB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Relationship Between MCP-1 Levels in GCF and Periodontitis: A Systematic Review With Meta-Analysis and Analysis of Molecular Interactions.Journal of cellular and molecular medicine · 2025Pooled it
- Improvement of post-periodontitis-therapy inflammatory state in diabetics: a meta-analysis of randomized controlled trials.Clinical oral investigations · 2024Pooled it
- Serum cytokines in periodontal diseases.Periodontology 2000 · 2025Review
- Article
- Pathogenic Mechanisms That May Link Periodontal Disease and Type 2 Diabetes Mellitus-The Role of Oxidative Stress.International journal of molecular sciences · 2024Review
- Relationship between salivary levels of interleukin-8 and HbA1c in patients with type 2 diabetes.Endocrinology, diabetes & metabolism · 2023Article
- Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus.Biomedicines · 2023Article
- Investigation of the Correlation Between the Polymorphism/Expression Level of RANTES and Its Receptor CCR5 Gene Promoter and Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.Periodontology 2000 · 2021Review
- Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation.The Journal of biological chemistry · 2019Article
- The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit.Clinical oral investigations · 2019Article
- Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link?Journal of immunology research · 2018Review
- Integrated biomarker profiling of smokers with periodontitis.Journal of clinical periodontology · 2017Article
- L-Cysteine supplementation increases adiponectin synthesis and secretion, and GLUT4 and glucose utilization by upregulating disulfide bond A-like protein expression mediated by MCP-1 inhibition in 3T3-L1 adipocytes exposed to high glucose.Molecular and cellular biochemistry · 2016Article
- Effects of metformin on blood and urine pro-inflammatory mediators in patients with type 2 diabetes.Journal of inflammation (London, England) · 2016Article
- Toll-like receptor 2 and type 2 diabetes.Cellular & molecular biology letters · 2016Review
- Influence of type 2 diabetes on local production of inflammatory molecules in adults with and without chronic periodontitis: a cross-sectional study.BMC oral health · 2015Article
- Cell culture conditions: from outer space-like conditions to the mimicking of complex in vivo environments.Journal of applied oral science : revista FOB · 2014Article
- Effect of scaling and root planing on gingival crevicular fluid level of YKL-40 acute phase protein in chronic periodontitis patients with or without type 2 diabetes mellitus: A clinico-biochemical study.Journal of Indian Society of PeriodontologyArticle
- Molecular Signature of the Immune Response to Yoga Therapy in Stress-related Chronic Disease Conditions: An Insight.International journal of yogaReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDiabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.
objectiveThis study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis. MATERIAL AND
methodsForty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA.
resultsDMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels.
conclusionsAlthough periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.
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