ReviewThe journal of nutrition, health & aging2014
An overview of structure, mechanical properties, and treatment for age-related tendinopathy.
Review in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- One-Year Trajectory of Pain, Function, and Health-Related Quality of Life in Patients With Plantar Fasciopathy.Journal of foot and ankle research · 2025Trial
- Mitochondrial destabilization in tendinopathy and potential therapeutic strategies.Journal of orthopaedic translation · 2024Review
- Molar root canal treatment performed by undergraduate dental students; an observational study of procedural errors and student perception.BMC medical education · 2024Observational
- Current and future advances in practice: tendinopathies of the hip.Rheumatology advances in practice · 2024Review
- A Comparison of Achilles Tendon Morphological Characteristics Based Upon VISA-A Score in Active Adults Over Age 50.International journal of exercise science · 2024Article
- Reoperation Following Zone II Flexor Tendon Repair.Hand (New York, N.Y.) · 2023Article
- Metformin improves tendon degeneration by blocking translocation of HMGB1 and suppressing tendon inflammation and senescence in aging mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Factors associated with lower limb tendinopathy in a large cohort of runners: a survey with a particular focus on nutrition.BMJ open sport & exercise medicine · 2023Article
- Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress.Frontiers in pharmacology · 2023Article
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- Revascularization character of autologous fascia lata graft following shoulder superior capsule reconstruction by enhanced magnetic resonance imaging.Journal of orthopaedic surgery and research · 2022Article
- Shear wave elastography imaging in a porcine tendinopathy model.Skeletal radiology · 2022Article
- TGFβ1-transfected tendon stem cells promote tendon fibrosis.Journal of orthopaedic surgery and research · 2022Article
- Influence of mechanical and TGF-β3 stimulation on the tenogenic differentiation of tonsil-derived mesenchymal stem cells.BMC molecular and cell biology · 2022Article
- The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons.International journal of molecular sciences · 2021Article
- Failed Surgery for Patellar Tendinopathy in Athletes: Midterm Results of Further Surgical Management.Orthopaedic journal of sports medicine · 2021Article
- [Advance of diagnosis and treatment of Haglund syndrome].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Review
- The cellular basis of fibrotic tendon healing: challenges and opportunities.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Prevalence and incidence rate of lower-extremity tendinopathies in a Danish general practice: a registry-based study.BMC musculoskeletal disorders · 2019Article
- Donor age affects proteome composition of tenocyte-derived engineered tendon.BMC biotechnology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendons transfer tensile loads from muscle to bone, which enable joint motions and stabilize joints. Tendons sustain large mechanical loads in vivo and as a result, tendons were frequently injured. Aging has been confirmed as a predisposing factor of tendinopathy and bad recovery quality following tendon repair. Current treatment methods are generally not effective and involve either symptomatic relief with non-steroidal antiinflammatory drugs and physical therapy or surgery when conservative treatments failed. The limitation in treatment options is due to our incomplete knowledge of age-related tendinopathy. Studies over the past decades have uncovered a number of important mechanical and cellular changes of aging tendon. However, the basis of aging as a major risk factor for tendon injury and impaired tendon healing remained poorly understood. The objectives of this review are to provide an overview of the current knowledge about the aging-associated changes of structure, mechanical properties and treatment in tendon and highlight causes and therapies for age-related tendinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.