ReviewCell cycle (Georgetown, Tex.)2014
Divide and differentiate: CDK/Cyclins and the art of development.
Review in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation inbioRxiv : the preprint server for biology · 2026Article
- A Huluwa phosphorylation switch regulates embryonic axis induction.Nature communications · 2024Article
- Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.Scientific reports · 2024Article
- LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway.Bioengineered · 2022Article
- EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation ofFrontiers in microbiology · 2022Article
- HTR7 promotes laryngeal cancer growth through PI3K/AKT pathway activation.Annals of translational medicine · 2021Article
- CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6.Journal of Cancer · 2021Article
- Role of cyclins and cyclin-dependent kinases in pluripotent stem cells and their potential as a therapeutic target.Seminars in cell & developmental biology · 2020Review
- Coordinating Proliferation, Polarity, and Cell Fate in theFrontiers in cell and developmental biology · 2020Review
- A Comprehensive Review on Schisandrin B and Its Biological Properties.Oxidative medicine and cellular longevity · 2020Review
- A novel CDK-2 homolog identified in lamprey, Lampetra japonica, with roles in apoptosis.Fish physiology and biochemistry · 2019Article
- Dlx5 and Dlx6 can antagonize cell division at the GBMC molecular and cell biology · 2019Article
- Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.Scientific reports · 2017Article
- PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer.Journal of experimental & clinical cancer research : CR · 2017Article
- The Functions of Serine 687 Phosphorylation of Human DNA Polymerase η in UV Damage Tolerance.Molecular & cellular proteomics : MCP · 2016Article
- Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration.Investigative ophthalmology & visual science · 2016Article
- Systematic study of the dynamics and half-lives of newly synthesized proteins in human cells.Chemical science · 2016Article
- Insulin-like growth factor binding protein-3 is a new predictor of radiosensitivity on esophageal squamous cell carcinoma.Scientific reports · 2015Article
- RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway.Oncotarget · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The elegant choreography of metazoan development demands exquisite regulation of cell-division timing, orientation, and asymmetry. In this review, we discuss studies in Drosophila and C. elegans that reveal how the cell cycle machinery, comprised of cyclin-dependent kinase (CDK) and cyclins functions as a master regulator of development. We provide examples of how CDK/cyclins: (1) regulate the asymmetric localization and timely destruction of cell fate determinants; (2) couple signaling to the control of cell division orientation; and (3) maintain mitotic zones for stem cell proliferation. These studies illustrate how the core cell cycle machinery should be viewed not merely as an engine that drives the cell cycle forward, but rather as a dynamic regulator that integrates the cell-division cycle with cellular differentiation, ensuring the coherent and faithful execution of developmental programs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.