ArticlePLoS genetics2014
An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Partitioning of the truncated insulin receptor DAF-2B between homodimers and heterodimers influences insulin signaling in C. elegans.PLoS genetics · 2026Article
- The neuropeptide neuromedin U receptor NMUR-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival.PLoS genetics · 2026Article
- Three muscle-specific DAF-16/FOXO transcriptional targets activated by reduced insulin/IGF-1 signaling.G3 (Bethesda, Md.) · 2026Article
- Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth.Nature communications · 2025Article
- Nictation behavior in nematodes.BMC biology · 2025Review
- Transcriptomic insights into the healthspan-enhancing effects of C. chinensis seed and E. ulmoides bark extracts in Caenorhabditis elegans.Biogerontology · 2025Article
- Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.Science advances · 2025Article
- Microbial Lipopolysaccharide Regulates Host Development Through Insulin/IGF-1 Signaling.International journal of molecular sciences · 2025Article
- The insulin-like peptide INS-27 mediates a muscle-to-neuron feedback signal coupling muscle activity with AMPA receptor trafficking.PLoS genetics · 2025Article
- Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.Cell genomics · 2024Article
- Sensory integration of food and population density during the diapause exit decision involves insulin-like signaling inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Bacterial vitamin B6 is required for post-embryonic development in C. elegans.Communications biology · 2024Article
- Sensory integration of food availability and population density during the diapause exit decision involves insulin-like signaling inbioRxiv : the preprint server for biology · 2024Article
- Article
- ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.PLoS biology · 2023Article
- The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states.Molecular psychiatry · 2023Review
- The SR protein RSP-2 influences expression of the truncated insulin receptor DAF-2B in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Dauer fate in aPeerJ · 2023Article
- The C. elegans truncated insulin receptor DAF-2B regulates survival of L1 arrested larvae.PloS one · 2023Article
- Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism.PLoS biology · 2022Article
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28 authors.
Funding
Abstract
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses. Our systematic studies identify an ILP-based combinatorial code for these phenotypes characterized by substantial functional specificity and diversity rather than global redundancy. Notably, we show that ILPs regulate each other transcriptionally, uncovering an ILP-to-ILP regulatory network that underlies the combinatorial phenotypic coding by the ILP family. Extensive analyses of genetic interactions among ILPs reveal how their signals are integrated. A combined analysis of these functional and regulatory ILP interactions identifies local genetic circuits that act in parallel and interact by crosstalk, feedback and compensation. This organization provides emergent mechanisms for phenotypic specificity and graded regulation for the combinatorial phenotypic coding we observe. Our findings also provide insights into how large hormonal networks regulate diverse traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.