Evidence map›Paper›PMID 24675717›Full record

Trial reportPloS one2014

Urinary TIMP-2 and IGFBP7 as early biomarkers of acute kidney injury and renal recovery following cardiac surgery.

Melanie Meersch, Christoph Schmidt, Hugo Van Aken, Sven Martens, Jan Rossaint, Kai Singbartl, Dennis Görlich, John A Kellum, Alexander Zarbock

4 registry-linked trialsOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 195 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 13 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02261909 withdrawnnot on this mapstarted 2015, after this paper: background citation

New Prognostic Kidney Function Markers in Emergency Patients

TypeobservationalSponsorKrankenhaus Barmherzige Brüder, RegensburgRan2015 to 2016Enrolled0ConditionsAcute Kidney Injury, Contrast Media
NCT02553174 terminatednot on this mapstarted 2016, after this paper: background citation

Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery

TypeobservationalSponsorMilton S. Hershey Medical CenterRan2016 to 2018Enrolled50ConditionsAcute Kidney Injury
NCT02598271 completednot on this mapstarted 2016, after this paper: background citation

Influence of Elevated Baseline Serum Creatinine and Body Composition on Acute Kidney Injury in Cardiac Surgery - The InCreAS Trial

TypeobservationalSponsorMedical University of ViennaRan2016 to 2022Enrolled200ConditionsAcute Kidney Injury
NCT02827448 completednot on this mapstarted 2015, after this paper: background citation

Urinary Cell Cycle Arrest Biomarkers as Early Predictors of Acute Kidney Injury Following Advanced Cardiac Replacement Therapies

TypeobservationalSponsorBaylor Research InstituteRan2015 to 2018Enrolled300ConditionsAcute Kidney Injury, Heart Failure
3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 13 syntheses or guidelines pooled it, 431 citations in OpenAlex.

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  9. Biomarkers of acute kidney injury in pediatric cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2022
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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Melanie MeerschDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Christoph SchmidtDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Hugo Van AkenDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Sven MartensDepartment of Cardiac Surgery, University of Münster, Germany.
Jan RossaintDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Kai SingbartlDepartment of Anesthesiology, Penn State College of Medicine, Hershey, Pennsylvania, United States of America.
Dennis GörlichInstitute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
John A KellumCenter for Critical Care Nephrology, CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania, United States of America.
Alexander ZarbockDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
University of Münster · DEPenn State Milton S. Hershey Medical Center · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifficulties in prediction and early identification of (acute kidney injury) AKI have hindered the ability to develop preventive and therapeutic measures for this syndrome. We tested the hypothesis that a urine test measuring insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in acute kidney injury (AKI), could predict AKI in cardiac surgery patients.

methodsWe studied 50 patients at high risk for AKI undergoing cardiac surgery with cardiopulmonary bypass (CPB). Serial urine samples were analyzed for [TIMP-2]*[IGFBP7] concentrations. The primary outcome measure was AKI as defined by international consensus criteria following surgery. Furthermore, we investigated whether urine [TIMP-2]*[IGFBP7] could predict renal recovery from AKI prior to hospital discharge.

results26 patients (52%) developed AKI. Diagnosis based on serum creatinine and/or oliguria did not occur until 1-3 days after CPB. In contrast, urine concentration of [TIMP-2]*[IGFBP7] rose from a mean of 0.49 (SE 0.24) at baseline to 1.51 (SE 0.57) 4 h after CPB in patients who developed AKI. The maximum urinary [TIMP-2]*[IGFBP7] concentration achieved in the first 24 hours following surgery (composite time point) demonstrated an area under the receiver-operating characteristic curve of 0.84. Sensitivity was 0.92, and specificity was 0.81 for a cutoff value of 0.50. The decline in urinary [TIMP-2]*[IGFBP7] values was the strongest predictor for renal recovery.

conclusionsUrinary [TIMP-2]*[IGFBP7] serves as a sensitive and specific biomarker to predict AKI early after cardiac surgery and to predict renal recovery. CLINICAL TRIAL REGISTRATION INFORMATION: www.germanctr.de/, DRKS-ID: DRKS00005062.

Indexed as

Postoperative ComplicationsAcute Kidney InjuryAgedAged, 80 and overArea Under CurveBiomarkersCardiopulmonary BypassCreatinineFemaleGene ExpressionHeart FailureHumansInsulin-Like Growth Factor Binding ProteinsMalePrognosisROC CurveBiomarkersCreatinineinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2

Identifiers

PMID24675717
PMCPMC3968141
OpenAlexW2168729190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.