ArticlePLoS genetics2014
Dying cells protect survivors from radiation-induced cell death in Drosophila.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The signaling and regulatory functions of dying cells and cell corpses.Communications biology · 2026Review
- Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance.Cell communication and signaling : CCS · 2026Review
- Cell Death, Compensatory Proliferation, and Cell Competition.Annual review of genetics · 2025Review
- Messages from Beyond the Grave: How Can Drosophila Help Us Understand the Consequences of Apoptosis?Advances in experimental medicine and biology · 2025Review
- Article
- Article
- Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.Hereditas · 2022Article
- The constructive function of apoptosis: More than a dead-end job.Frontiers in cell and developmental biology · 2022Article
- Regulation and coordination of the different DNA damage responses inFrontiers in cell and developmental biology · 2022Review
- Article
- Comparative transcriptomic analysis reveals gene regulation mediated by caspase activity in a chordate organism.BMC molecular and cell biology · 2021Article
- Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer.Molecular cancer · 2020Article
- What Drosophila Can Teach Us About Radiation Biology of Human Cancers.Advances in experimental medicine and biology · 2019Review
- Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila.PLoS genetics · 2018Article
- A matter of life and death: stem cell survival in tissue regeneration and tumour formation.Nature reviews. Cancer · 2018Review
- An apoptosis-driven 'onco-regenerative niche': roles of tumour-associated macrophages and extracellular vesicles.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Loss ofeLife · 2017Article
- Assembly and Annotation of Transcriptome Provided Evidence of miRNA Mobility between Wheat and Wheat Stem Sawfly.Frontiers in plant science · 2017Article
- Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation.PLoS biology · 2016Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We report a phenomenon wherein induction of cell death by a variety of means in wing imaginal discs of Drosophila larvae resulted in the activation of an anti-apoptotic microRNA, bantam. Cells in the vicinity of dying cells also become harder to kill by ionizing radiation (IR)-induced apoptosis. Both ban activation and increased protection from IR required receptor tyrosine kinase Tie, which we identified in a genetic screen for modifiers of ban. tie mutants were hypersensitive to radiation, and radiation sensitivity of tie mutants was rescued by increased ban gene dosage. We propose that dying cells activate ban in surviving cells through Tie to make the latter cells harder to kill, thereby preserving tissues and ensuring organism survival. The protective effect we report differs from classical radiation bystander effect in which neighbors of irradiated cells become more prone to death. The protective effect also differs from the previously described effect of dying cells that results in proliferation of nearby cells in Drosophila larval discs. If conserved in mammals, a phenomenon in which dying cells make the rest harder to kill by IR could have implications for treatments that involve the sequential use of cytotoxic agents and radiation therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.